◀ Back to APOC3

APOC3 — VCAM1

Text-mined interactions from Literome

Kawakami et al., Circulation 2006 (Atherosclerosis...) : Apolipoprotein CIII induces expression of vascular cell adhesion molecule-1 in vascular endothelial cells and increases adhesion of monocytic cells ... ApoCIII increased EC expression of vascular cell adhesion molecule-1 ( VCAM-1 ) protein and intercellular cell adhesion molecule-1 ( ICAM-1 ) protein ( 4.9 +/- 1.5-fold and 1.4 +/- 0.5-fold versus control, respectively )
Zheng et al., Eur Heart J 2013 : ApoCIII significantly increased VCAM-1 expression in HSVECs and HCAECs ... Pre-treatment with statins suppressed apoCIII induced VCAM-1 expression and monocyte adhesion, with two lipophilic statins ( pitavastatin and atorvastatin ) exhibiting inhibitory effects at lower concentration than those of hydrophilic pravastatin ... Nuclear factor ?B ( NF-?B ) mediated apoCIII induced VCAM-1 expression, as demonstrated via loss-of-function experiments, and pitavastatin treatment suppressed NF-?B activation