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ANGPT2 — PAX2

Text-mined interactions from Literome

Zhang et al., Kidney Int 2004 : Ang II up-regulated Pax-2 gene expression via AT2R in IRPTC ... The stimulatory effect of both Ang II on Pax-2 gene expression was blocked by PD123319 ( AT2R inhibitor ), AG 490 ( specific Janus kinase 2 (JAK2) inhibitor ) and genistein ( tyrosine kinase inhibitor ), but not by losartan ( AT1R inhibitor ) ... Our studies suggest that Ang II stimulates Pax-2 gene expression in IRPTC via AT2R and the JAK2/signal transducers and activators of transcription ( STAT ) signaling transduction pathway, which may be important in renal repair following injury
Chen et al., Pediatr Nephrol 2008 : In ex vivo studies, Ang II stimulated Pax-2 and N-myc mRNA expression in embryonic kidneys of wild-type mice, but this stimulatory effect was absent in embryonic kidneys of AT(2)R KO mice