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RAD50 — RASA1
Text-mined interactions from Literome
Jordan et al., J Biol Chem 1999
:
Expression of chick
Rap1GAP in PC-12 cells
inhibited activation of
Rap1 by forskolin
McLeod et al., J Immunol 2002
:
Moreover, blocking the
activation of
Rap1 and Rap2 via the expression of a Rap-specific
GTPase activating protein significantly reduced the ability of B cells to migrate toward SDF-1
Nur-E-Kamal et al., Mol Biol Cell 1992
:
The
GAP1 ( also called Ras GAP ) is highly specific for Ras and does not
stimulate the intrinsic GTPase activity of
Rap1 or Rho
Schultess et al., Blood 2005
:
Phosphorylation of
Rap1GAP2 by cGKI might
mediate inhibitory effects of NO/cGMP on
Rap1
Maruta et al., J Biol Chem 1991
:
In this paper, we describe the enzymatic properties of several mutated Rap1A and chimeric Ras/Rap1A ( or -1B ) proteins which lead to the following conclusions : ( i ) the
GAP3 dependent activation of both
Rap1A and -1B GTPases requires Gly12, but neither Thr61 nor Gln63 ; ( ii ) residues 64 to 70 of the Rap1 GTPases are sufficient to determine their specificities for GAP3 ; and ( iii ) residues 61 to 65 of the Ras GTPases are sufficient for determining their specificities for GAP1
Nellore et al., J Clin Endocrinol Metab 2009
(Carcinoma, Papillary...) :
Rap1
GTPase activating protein (GAP) regulates the activity of
Rap1 , a putative oncogene ... In vitro, loss of
Rap1GAP was
sufficient to increase
Rap1 activity in thyroid cells
Zheng et al., Cancer Res 2009
(Melanoma) :
In the present study, we show that expression of
Rap1GAP , a specific negative
regulator of
Rap1 , is decreased in human melanoma tumors and cell lines ... Overexpression of
Rap1GAP in melanoma cells
blocks Rap1 activation and extracellular signal regulated kinase ( ERK ) phosphorylation and inhibits melanoma cell proliferation and survival
Zuo et al., Cancer Res 2010
(Carcinoma, Papillary, Follicular...) :
Rap1GAP , a Rap1 GTPase activating protein,
inhibits the RAS superfamily protein
Rap1 by facilitating hydrolysis of GTP to GDP
Frech et al., Science 1990
:
Rap1A-p21 was not
activated by
GAP but bound tightly to GAP and was an effective competitive inhibitor of GAP mediated Ras-GTPase activity
Janoueix-Lerosey et al., Biochem Biophys Res Commun 1994
:
This phosphorylation does not affect the
stimulation of the GTPase activity of
Rap1 by
Rap1GAP but may play a role in regulating the interaction of Rap1GAP with other proteins involved in the cellular functions regulated by Rap1 and Rap1GAP