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IDO1 — PTGS2

Text-mined interactions from Literome

Lee et al., J Immunother 2009 (Lung Neoplasms) : It was recently shown that maturation of dendritic cells in the presence of indoleamine 2, 3-dioxygenase ( IDO ) results in activation of Tregs, and inhibition of COX-2 activity regulated IDO expression within the tumor microenvironment
Zhang et al., Ann Surg Oncol 2011 (Colorectal Neoplasms) : Here, we analyzed the effect of indomethacin ( Indo , a nonselective COX-2 inhibitor ) and nimesulide ( Nim, a selective COX-2 inhibitor ) on mTOR signaling in CRC cells in vitro and in vivo to determine the dependence of this effect on COX-2
Mei et al., Mol Hum Reprod 2012 (Endometriosis) : Inhibition of IDO1 by L-1-MT suppressed the expression of COX-2 and MMP-9 in ESCs
Obermajer et al., Transplantation research 2012 : We observed that PGE2 induces endogenous cyclooxygenase (COX)2 expression in cultured monocytes, blocking their differentiation into CD1a+ dendritic cells (DCs) and inducing the expression of indoleamine 2,3-dioxygenase 1 , IL-4Ra, nitric oxide synthase 2 and IL-10 - typical MDSC associated suppressive factors
Spatz et al., Am J Physiol 1994 : Dexamethasone ( Dxm ), indomethacin (Indo) , and nordihydroguaiaretic acid, the respective inhibitors of PLA2-cyclooxygenase II , cyclooxygenase, and lipoxygenase, increased both constitutive and AVP- or ANG II-stimulated secretion of ET-1