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GNA12 — PTGS2

Text-mined interactions from Literome

Dermott et al., Oncogene 1999 (Cell Transformation, Neoplastic) : Furthermore, expression of Galpha12QL or the stimulation of wild-type Galpha12 induces the expression of COX-2
Ki et al., J Biol Chem 2007 : Galpha12 specifically regulates COX-2 induction by sphingosine 1-phosphate ... Gene knock-out and chemical inhibitor experiments revealed that the S1P induction of COX-2 requires Galpha(12) but not Galpha(13), Galpha ( q ), or Galpha ( i/o ) ... The specific role of Galpha(12) in COX-2 induction by S1P was verified by promoter luciferase assay, Galpha(12) transfection, and knockdown experiments ... S1P injection induced COX-2 in the lungs and livers of mice and increased plasma prostaglandin E ( 2 ), and these effects were prevented by Galpha(12) deficiency ... Our data indicate that, of the Galpha proteins coupled to S1P receptors, Galpha(12) specifically regulates NF-kappaB mediated COX-2 induction by S1P downstream of S1P ( 1 ), S1P(3), and S1P(5), in a process mediated by the JNK dependent ubiquitination and degradation of IkappaBalpha