Gene interactions and pathways from curated databases and text-mining

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CXCL10 — PTGS2

Text-mined interactions from Literome

Kanda et al., J Invest Dermatol 2002 (Carcinoma, Squamous Cell...) : We examined the in vitro effects of cyclooxygenase-2 inhibitor NS398 on IP-10 production in human epidermoid carcinoma A431
Põld et al., Cancer Res 2004 (Carcinoma, Non-Small-Cell Lung...) : Cyclooxygenase-2 dependent expression of angiogenic CXC chemokines ENA-78/CXC Ligand (CXCL) 5 and interleukin-8/CXCL8 in human non-small cell lung cancer ... To elucidate the role of COX-2 in the in vitro and in vivo expression of two known NSCLC angiogenic peptides, CXC ligand ( CXCL ) 8 and CXCL5, we studied two COX-2 gene modified NSCLC cell lines, A549 and H157 ... COX-2 overexpression enhanced the in vitro expression of both CXCL8 and CXCL5
Laine et al., Biochem Biophys Res Commun 2007 : Palmitic acid ( PA ), the predominant saturated FFA released from adipose tissue, but not unsaturated FFA, induced an approximately 6-fold ( p < 0.05 ) increase in IP-10 gene expression ( and 2- to 4-fold increases in IL-8, MCP-1, COX-2 , and MIG )
Brant et al., Toxicological sciences : an official journal of the Society of Toxicology 2009 : Consistent with our previous findings that Ni and MALP-2 stimulates the induction of CXCL8 via a COX-2 mediated pathway, CXCL1 , CXCL5, and VEGF release were also regulated by COX-2