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PLD2 — RAF1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: PLD2 → RAF1 (increases, RAF1 Activity, PLD2 Activity)
  Evidence: A role for PLD in cell proliferation is indicated from reports showing that PLD activity is elevated in response to platelet-derived growth factor (PDGF; 6), fibroblast growth factor (7, 8), epidermal growth factor (EGF; 9), insulin (10), insulin-like growth factor 1 (11), growth hormone (12), and sphingosine 1-phosphate (13). PLD activity is also elevated in cells transformed by a variety of transforming oncogenes including v-Src (14), v-Ras (15, 16), v-Fps (17), and v-Raf (18).

Text-mined interactions from Literome

Daniel et al., Biochim Biophys Acta 1999 : The role of phospholipase D in stimulation of Raf-1 and prostaglandin H synthase type-2 is emphasized
Lucas et al., Int J Oncol 2002 (Cell Transformation, Neoplastic) : Modulation of phospholipase D by Ras proteins mediated by its effectors Ral-GDS, PI3K and Raf-1