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CDH20 — PI3
Text-mined interactions from Literome
Goodwin et al., J Biol Chem 2003
:
In particular, homophilic
cadherin ligation can directly
activate Rho family GTPases and phosphatidylinositol 3-kinase (
PI3-kinase ), signaling molecules with the capacity to support the morphogenetic effects of these adhesion molecules during development and disease ... In contrast,
cadherin activated
PI3-kinase signaling was not affected by loss of p120-ctn binding
Owens et al., J Cell Sci 2003
(Cell Transformation, Neoplastic...) :
Responsiveness to TGFbeta could be restored by inhibiting
cadherin mediated cell-cell adhesion or
phosphoinositide 3-kinase (PI3-K) activity, but not by inhibiting mitogen activated protein kinase ( MAPK ) activity