Gene interactions and pathways from curated databases and text-mining

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APOE — PI3

Text-mined interactions from Literome

Huwait et al., Cell Signal 2011 : The expression of ApoE and ABCA1 induced by synthetic or natural LXR ligands [ TO901317, GW3965, and 22- ( R ) -hydroxycholesterol ( 22- ( R ) -HC ), respectively ] was attenuated by inhibitors of c-Jun N-terminal kinase (JNK) ( curcumin and SP600125 ) and phosphoinositide 3-kinase (PI3K) ( LY294002 )
Chen et al., J Biol Chem 2012 : In addition, both reelin and apoE3 significantly increased phosphorylated disabled-1 (Dab1), phosphatidylinositol 3-kinase (PI3K) , protein kinase C? ( PKC? ), and specificity protein 1 (Sp1)