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ABL1 — PI3

Text-mined interactions from Literome

Nieborowska-Skorska et al., Oncogene 2000 (Leukemia, Myeloid) : We show here that the defect in activation of PI-3k/Akt by BCR/ABL DeltaSH2 mutant ( SH2 domain deleted ) and of STAT5 by BCR/ABL DeltaSH3+DeltaSH2 mutant ( SH3 and SH2 domains deleted ) is not permanent and both Akt and STAT5 could be ` re-activated ' by in vitro culture
van der Kuip et al., Blood 2001 : Thus, cooperative activation of PI-3K/AKT by Bcr-Abl and integrins causes synergistic protection of Bcr-Abl+ cells from DNA damage induced apoptosis
Ghosh-Choudhury et al., J Biol Chem 2013 : Remarkably, inhibition of c-Abl significantly suppressed BMP-2 stimulated PI 3-kinase activity and its downstream Akt phosphorylation
Kharbanda et al., Oncogene 1998 : In addition, c-Abl dependent inhibition of PI 3-kinase contributes to the induction of apoptosis