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HRG — PCNA

Text-mined interactions from Literome

Yang et al., Biochem J 2008 (Breast Neoplasms) : In the present paper we report that Rac1 is an essential player for mediating the induction of cyclin D1 and p21(Cip1) by HRG in breast cancer cells ... Inhibition of Rac function by expressing either the Rac-GAP ( GTPase activating protein ) beta2-chimaerin or the dominant negative Rac mutant N17Rac1, or Rac1 depletion using RNAi ( RNA interference ), abolished the cyclin D1 and p21(Cip1) induction by HRG ... Inhibition of EGFR, PI3K ( phosphoinositide 3-kinase ; kinases required for Rac activation by HRG ) or MEK [ MAPK ( mitogen activated protein kinase ) /ERK ( extracellular-signal regulated kinase ) kinase ] also blocked the up-regulation of cyclin D1 and p21(Cip1) by HRG
Fiddes et al., Oncogene 1998 (Breast Neoplasms) : HRG stimulation led to sequential induction of c-myc, cyclin D1, cyclin E and cyclin A gene expression and hyperphosphorylation of the retinoblastoma protein pRB