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CDKN1C — PCNA

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PCNA — CDKN1C (direct interaction, two hybrid) Watanabe et al., Proc Natl Acad Sci U S A 1998*
• IRef Biogrid Interaction: PCNA — CDKN1C (physical association, affinity chromatography technology) Watanabe et al., Proc Natl Acad Sci U S A 1998*
• IRef Biogrid Interaction: PCNA — CDKN1C (direct interaction, pull down) Watanabe et al., Proc Natl Acad Sci U S A 1998*
• IRef Hprd Interaction: PCNA — CDKN1C (in vivo) Watanabe et al., Proc Natl Acad Sci U S A 1998*
• IRef Hprd Interaction: PCNA — CDKN1C (in vitro) Watanabe et al., Proc Natl Acad Sci U S A 1998*
• IRef Intact Interaction: PCNA — CDKN1C (physical association, anti tag coimmunoprecipitation) Arboleda et al., Nat Genet 2012*
• IRef Ophid Interaction: PCNA — CDKN1C (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: PCNA — CDKN1C (aggregation, confirmational text mining) Watanabe et al., Proc Natl Acad Sci U S A 1998*

Text-mined interactions from Literome

Reynaud et al., Mol Cell Biol 1999 : We show that expression of p57(Kip2) , a potent tight binding inhibitor of several G ( 1 ) cyclin-cyclin dependent kinase (Cdk) complexes, increases markedly during C2C12 myoblast differentiation ... Taken together, our data suggest that repression of cyclin E-Cdk2 mediated phosphorylation of MyoD by p57(Kip2) could play an important role in the accumulation of MyoD at the onset of myoblast differentiation
Kanayama et al., Mol Hum Reprod 2002 (Hypertension...) : p57Kip2 , a potent inhibitor of several cyclin/cyclin dependent kinase complexes (CDK ), is a paternally imprinted gene in both humans and mice, and here we show that pregnant mice which are heterozygous for p57Kip2 deficiency display symptoms similar to preeclampsia
Li et al., J Immunol 2004 : Most notably, increased p57(Kip2) levels resulted in marked inhibition of both cyclin E- and cyclin A-associated cdk2 kinase activities and a decrease in cyclin A amounts
Nakano et al., Biochem Biophys Res Commun 2005 : Supplemental overexpression of p57(kip2) inhibited the activations of G1 cyclin/CDKs and subsequent hyperphosphorylations of all three retinoblastoma pocket proteins as well as G1/S transition of cell cycle
Kim et al., Arch Androl 2006 (Azoospermia) : p57kip2 , a KIP family cyclin dependent kinase (Cdk) inhibitor , blocks the cell cycle by acting on multiple cyclin-Cdk complexes
Yamamoto et al., Toxicol Appl Pharmacol 2007 (Mouth Neoplasms) : In normal human primary epidermal keratinocytes ( NHEK ), one of the key mediators of EGCG action is p57/KIP2 , a cyclin dependent kinase (CDK) inhibitor
Taylor et al., Journal of translational medicine 2008 (Hepatitis C) : CDKN1C ( cyclin kinase inhibitor 1 ) was induced early but repressed at later times
Romanelli et al., Am J Med Genet A 2010 (Beckwith-Wiedemann Syndrome) : A small number of individuals with BWS ( 5-10 % ) have mutations in CDKN1C , a cyclin dependent kinase inhibitor of G1 cyclin complexes that functions as a negative regulator of cellular growth and proliferation
Matsuoka et al., Genes Dev 1995 : p57KIP2 is a potent, tight binding inhibitor of several G1 cyclin/Cdk complexes, and its binding is cyclin dependent