◀ Back to MMP14

CD44 — MMP14

Text-mined interactions from Literome

Mori et al., EMBO J 2002 : CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain ... Overexpression of a CD44H mutant lacking the cytoplasmic tail also prevented MT1-MMP from localizing at the lamellipodia
Annabi et al., J Neurochem 2005 (Brain Neoplasms...) : Treatment of glioma cells with the Rho-kinase (ROK) inhibitor Y27632, or with EGCg, a green tea catechin with anti-MMP and anti-angiogenesis activities, antagonized both RhoA- and MT1-MMP induced CD44 shedding
Huh et al., J Cell Biochem 2007 : Both CD44v6 and its ectodomain cleavage products were detected from ED 5 to ED 14, and a broad-spectrum MMP inhibitor blocked ectodomain cleavage in cultured stromal cells
Campo et al., Biochim Biophys Acta 2009 : HA treatment produced different effects : low MW HA up-regulated CD44 expression, increased PKCdelta and PKCepsilon levels, and enhanced inflammation in untreated chondrocytes ; while in PMA treated cells it increased CD44, PKCdelta, PKCepsilon, NF-kB, TNF-alpha, IL-1beta, MMP-13 , and iNOS expression and enhanced the effects of PMA ; medium MW HA did not exert action ; high MW HA had no effect on untreated chondrocytes ; however, it reduced PKCdelta, PKCepsilon, NF-kB activation and inflammation in PMA stimulated cells