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MAPK4 — RASGRF2

Text-mined interactions from Literome

Arozarena et al., J Biol Chem 2000 : We show that GDP- but not GTP bound Cdc42 prevents Ras-GRF recruitment to the membrane and activation of Ras/MAPK , although no direct association of Ras-GRF with Cdc42 was detected ... We also demonstrate that catalyzing GDP/GTP exchange on Cdc42 facilitates Ras-GRF induced MAPK activation ... Moreover, we show that the potentiating effect of ionomycin on Ras-GRF mediated MAPK stimulation is also regulated by Cdc42
Zippel et al., Exp Cell Res 2000 (Calcium Signaling) : Here we show that when expressed in different cell lines Ras-GRF1 strongly enhances the level of active Ras ( Ras-GTP ) and the activity of mitogen activated protein kinases ( MAPK ) ... Calmodulin and cytosolic free calcium are essential for Ras and MAPK activation induced by LPA and mediated by Ras-GRF1 , as shown by the finding that BAPTA-AM, an intracellular calcium chelator, and calmodulin inhibitors completely abolished this effect
Arozarena et al., J Biol Chem 2001 (MAP Kinase Signaling System) : Here, we report that retaining Cdc42 in its GDP bound state by overexpressing Rho-GDI inhibits Ras-GRF mediated MAPK activation
Fam et al., Mol Cell Biol 1997 : Transient expression of Ras-GRF2 in kidney epithelial cells stimulated GTP binding by Ras and potentiated calcium ionophore induced activation of mitogen activated protein kinase ( ERK1 ) dependent upon the IQ motif