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Weinkauf et al., Infect Immun 2009
(Chagas Disease) :
PDNF promotes TrkC dependent mitogen activated protein kinase signaling, neurite outgrowth, and survival of genetically engineered PC12 neuronal cells and glial Schwann cells in a TrkC dependent manner
Guiton et al., J Biol Chem 1995
:
In cells expressing full-length TrkC, neurotrophin-3 promoted a sustained activation of mitogen activated protein kinase ; TrkC containing kinase inserts only mediated transient activation of mitogen activated protein kinase Gunn-Moore et al., Biochem J 1997
:
Experiments with the use of cell-permeant inhibitors argue against a major role for PLC gamma and PtdIns 3-kinase in the activation of MAPK by TrkC