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CNR1 — MAPK4

Text-mined interactions from Literome

Howlett et al., Prostaglandins Other Lipid Mediat 2002 : are G protein coupled receptors that are coupled through the Gi/o family of proteins to signal transduction mechanisms that include inhibition of adenylyl cyclase, activation of mitogen activated protein kinase , regulation of calcium and potassium channels ( CB1 only ), and other signal transduction pathways
Howlett et al., Neuropharmacology 2004 : CB1 receptors couple to G ( i/o ) to inhibit cAMP production, decrease Ca2+ conductance, increase K+ conductance, and increase mitogen activated protein kinase activity
Bari et al., J Immunol 2006 : Recently, we have shown that treatment of rat C6 glioma cells with the raft disruptor methyl-beta-cyclodextrin (MCD) doubles the binding of anandamide ( AEA ) to type-1 cannabinoid receptors ( CB1R ), followed by CB1R dependent signaling via adenylate cyclase and p42/p44 MAPK activity
Börner et al., J Leukoc Biol 2007 : An increase in CB1 mediated phosphorylation of MAPK in cells prestimulated with CB2-specific agonists suggests up-regulation of functional CB1 receptor proteins
Mukhopadhyay et al., Br J Pharmacol 2010 (Disease Models, Animal...) : Both genetic deletion and pharmacological inhibition of CB(1) receptors with AM281 or SR141716 markedly attenuated the cisplatin induced renal dysfunction and interrelated oxidative/nitrosative stress, p38 and JNK MAPK activation, cell death and inflammatory response in the kidney
Signorello et al., J Cell Biochem 2011 : The 2-AG effect on p38MAPK was not impaired by apyrase, indomethacin or RGDS peptide but it was significantly reduced by SR141716, specific inhibitor of type-1 cannabinoid receptor and unaffected by the specific inhibitor of type-2 cannabinoid receptor SR144528