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Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
Complex of CRK-RAPGEF1
→
INSR
(increases, INSR Translocation, CRK/RAPGEF1 Activity)
Evidence: Translocation of phosphorylated Cbl recruits the adapter protein CrkII to the lipid raft via interaction of the SH2 domain of CrkII with phospho-Cbl51. CrkII also forms a constitutive complex with the guanyl nucleotide-exchange protein C3G. Once translocated into lipid rafts, C3G comes into proximity with the G protein TC10, and catalyses the exchange of GTP for GDP, resulting in the activation of the protein51.
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *