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IL6 — PLG

Text-mined interactions from Literome

Cirillo et al., Mol Cell Biol 1999 : Role of distinct mitogen activated protein kinase pathways and cooperation between Ets-2, ATF-2, and Jun family members in human urokinase-type plasminogen activator gene induction by interleukin-1 and tetradecanoyl phorbol acetate
Marsik et al., Cardiovasc Res 2003 (Disseminated Intravascular Coagulation) : Infusion of LPS increased interleukin-6 levels 400 fold, and induced a 10-fold increase in prothrombin fragment, a fourfold increase in D-dimer, and a fivefold increase in plasmin-antiplasmin complexes
Bannach et al., Journal of thrombosis and haemostasis : JTH 2004 (Acute-Phase Reaction...) : Interleukin-6 induced plasminogen gene expression in murine hepatocytes is mediated by transcription factor CCAAT/enhancer binding protein beta ( C/EBPbeta ) ... For the present study, we investigated the transcription factors and signaling pathway mediating the response of the plasminogen gene to IL-6 ... Treatment of Hepa 1-6 cells with the mitogen activated protein kinase ( MAPK ) inhibitor, PD-98059, inhibited IL-6 stimulated plasminogen promoter activity ... These results suggest that transcription factor C/EBPbeta and the MAPK pathway play key roles in the response of the plasminogen gene to IL-6 , thus elucidating a major mechanism by which the plasminogen system is upregulated to perform its crucial functions in the acute-phase response
Li et al., Arterioscler Thromb Vasc Biol 2007 (Atherosclerosis...) : Inhibitors of JAK, p38, and NF-kappaB revealed that these signaling pathways are indispensable for the plasmin mediated tumor necrosis factor-alpha and IL-6 induction
Chae et al., Immunopharmacol Immunotoxicol 2007 (Second Messenger Systems) : Moreover, IL-6 increased the activity of urokinase type plasminogen activator ( uPA ) in MG-63 cells, which was inhibited by SB203580, PDTC and NF-kappaB SN50
Vaschetto et al., Anesthesiology 2008 (Wounds and Injuries) : This was associated with a decreased level of interleukin 6 , active plasminogen activator inhibitor 1 in the lung, attenuated leukocyte lung transmigration, and reduced pulmonary edema and apoptosis
Larsson et al., Thromb Res 2008 : Effects of IL-1beta and IL-6 on tissue-type plasminogen activator expression in vascular endothelial cells
Bryan et al., Mol Cancer Res 2008 (Brain Neoplasms...) : Sphingosine-1-phosphate and interleukin-1 independently regulate plasminogen activator inhibitor-1 and urokinase-type plasminogen activator receptor expression in glioblastoma cells : implications for invasiveness
Andrews et al., Biochim Biophys Acta 1990 (Arthritis, Rheumatoid) : No stimulation of plasminogen activator activity was seen in response to either preparation of interleukin 1, and in more than half of the cell cultures interleukin 1 caused a significant decrease in the secreted levels of PA activity
Kocić et al., Int J Biochem Cell Biol 2013 (MAP Kinase Signaling System) : Our results demonstrated that interleukin-17 strongly inhibits urokinase type plasminogen activator expression during myogenic differentiation
Mochan et al., Arthritis Rheum 1986 : Evidence that interleukin-1 induction of synovial cell plasminogen activator is mediated via prostaglandin E2 and cAMP
Bunning et al., Biochim Biophys Acta 1987 : The stimulation of plasminogen activator activity can be abolished by preincubation of placental interleukin 1 with an antiserum to homogeneous 22K factor, a species of interleukin 1 beta, indicating that the stimulation of plasminogen activator activity is due to interleukin 1 and not contaminating factors
Ng et al., J Biol Chem 1994 : Although tumor necrosis factor (TNF) and interleukin-1 ( IL ) induce the expression of the IL-8, TNF stimulated gene 6, and plasminogen activation inhibitor-2 genes and the activation of NF-kappa B with nearly identical kinetics, the two cytokines differ significantly in the induction of the IL-6 gene in all primary fibroblasts tested
Samad et al., Biochim Biophys Acta 1994 : Regulation of plasminogen activation by interleukin-6 in human lung fibroblasts
Panozzo et al., Int J Clin Lab Res 1996 (Colonic Neoplasms...) : Interleukin-1 alpha slightly stimulated cell growth, but inhibited plasminogen activator inhibitor-1 production in both cell lines ; interleukin-1 beta did not affect cell growth, but stimulated plasminogen activator inhibitor-1 production by the colon cancer cell line
Kida et al., Biochem Biophys Res Commun 1997 (Carcinoma, Hepatocellular...) : Since the PLG gene has three sequences for the interleukin-6 (IL-6) responsive element, we examined the effect of IL-6 on the PLG expression
Jenkins et al., Blood 1997 (Carcinoma, Hepatocellular...) : We examined the effects of recombinant human interleukin-6 ( rhIL-6 ), a pleiotropic cytokine, on plasminogen mRNA expression in primary murine hepatocytes and Hep3B human hepatoma cells
Wilson et al., Exp Nephrol 1997 (Nephritis) : Opposing effects of interleukin-1 and transforming growth factor-beta on the regulation of tissue-type plasminogen activator and plasminogen activator inhibitor type-1 expression by human mesangial cells
Hurwitz et al., Mol Cell Endocrinol 1994 : Cytokine mediated regulation of rat ovarian function : interleukin-1 inhibits plasminogen activator activity through the induction of plasminogen activator inhibitor-1 ( PAI-1 )
Hosoya et al., J Endod 1998 : Stimulatory effect of interleukin-6 on plasminogen activator activity from human dental pulp cells