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CLEC7A — IL6

Text-mined interactions from Literome

Meyer-Wentrup et al., J Immunol 2007 : Dectin-1 interaction with tetraspanin CD37 inhibits IL-6 production ... Although CD37 deficiency does not affect dectin-1 mediated phagocytosis, we observed a striking 10-fold increase of dectin-1 induced IL-6 production in CD37 ( -/- ) macrophages compared with wild-type cells, despite reduced dectin-1 cell surface expression ... Taken together, these findings show that tetraspanin CD37 is important for dectin-1 stabilization in APC membranes and controls dectin-1 mediated IL-6 production
Mezger et al., J Infect Dis 2008 (Aspergillosis) : Silencing of dectin-1 resulted in reduced expression of proinflammatory cytokines ( tumor necrosis factor-alpha and interleukin-12 ), which was also reduced by anti-Dectin-1 antibody treatment prior to exposure to A. fumigatus, zymosan, or Candida albicans
Salazar-Aldrete et al., J Clin Immunol 2013 (Arthritis, Rheumatoid...) : In addition, cells from SLE patients showed an abnormal calcium flux response induced by dectin-1 ligands as well as an enhanced release of IL-1ß, IL-6 and TNF-a, but not IL-23, upon dectin-1 engagement
Mintz-Cole et al., J Allergy Clin Immunol 2013 (Asthma) : Furthermore, the production of TH17 skewing IL-6 , IL-23, and TNF-a by dendritic cells in response to heat killed C cladosporioides was dependent on Dectin-1
Leal et al., PLoS Pathog 2013 : Utilizing in vitro neutrophil killing assays and a model of fungal infection of the cornea, we demonstrated that Dectin-1 dependent IL-6 production regulates expression of iron chelators, heme and siderophore binding proteins and hepcidin in infected mice