◀ Back to IL12A
CD8A — IL12A
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Grohmann et al., J Immunol 1999
(Hypersensitivity, Delayed) :
IL-12 acts selectively on
CD8 alpha- dendritic cells to enhance presentation of a tumor peptide in vivo
Lamousé-Smith et al., J Immunol 1999
:
In this study, we have investigated in detail the cytokine requirements for the generation of allospecific CD8+ CTL in vitro and have found that IL-4 can augment the generation of anti-CD8-sensitive but not anti-CD8-resistant CTL, whereas IL-2 or
IL-12 can
augment the generation of both
anti-CD8-sensitive and anti-CD8-resistant CTL
Gherardi et al., J Virol 2000
:
Moreover, at certain viral doses, coadministration of the NO inhibitor during the booster resulted in
IL-12 mediated enhancement of the specific
CD8 ( + ) T-cell response
Lin et al., Pediatr Allergy Immunol 2001
:
Combining
IL-12 and IL-15, however,
resulted in decreased CB CD3+
CD8+ expression compared with IL-15 alone
Gorbachev et al., J Immunol 2001
(Dermatitis, Contact) :
In the current report we tested the
role of
IL-12 on
CD8 ( + ) T cell development during sensitization and elicitation of CHS to dinitrofluorobenzene
Grohmann et al., J Immunol 2001
:
By virtue of their respective actions on CD8 ( - ) and CD8 ( + ) DC,
IL-12 and IFN-gamma have functionally opposing effects on peptide presentation by the CD8 ( - ) DC subset, and IFN-gamma activated
CD8 ( + ) DC
mediate tolerogenic effects that prevail over the adjuvant activity of IL-12 on CD8 ( - ) DC
Iwasaki et al., Eur J Immunol 2001
(Calcium Signaling) :
A critical role for
IL-12 in CCR5 induction on T cell receptor
triggered mouse CD4 ( + ) and
CD8 ( + ) T cells
Mocikat et al., Immunity 2003
(Carcinoma...) :
The activated NK cells then prime DC to produce
IL-12 and to
induce highly protective
CD8 T cell memory responses
Soumelis et al., Springer Semin Immunopathol 2004
(Hypersensitivity...) :
TSLP activated human DCs produce Th2 attracting chemokines but no
IL-12 , and
induce naive CD4 ( + ) and
CD8 ( + ) T cell differentiation into effector cells with a typical pro-allergic phenotype
Gruber et al., Cancer Gene Ther 2005
(Philadelphia Chromosome...) :
We found that
IL-12 was able to eliminate pre established leukemia, and that this protection was
mediated by CD4,
CD8 , and NK cells in combination
Boyer et al., J Med Primatol 2005
(Monkey Diseases...) :
The adjuvanted DNA vaccines illustrate that
IL-12 enhances a
CD8 vaccine immune response, however, different cellular profiles
Wüthrich et al., J Immunol 2005
(Blastomycosis...) :
CD4 ( + ) T cells absolutely required IL-12 to control a live genetically engineered attenuated strain of Blastomyces dermatitidis given s.c. as a vaccine, whereas
CD8 ( + ) T cells were significantly less
dependent on
IL-12
Kupfahl et al., Int Immunopharmacol 2006
(Listeriosis) :
In summary these results show that lentinan enhances the protective CD8 T-cell response against L. monocytogenes probably by a mechanism that involves the
IL-12 mediated augmentation of the specific antilisterial
CD8 T-cell response
Blachère et al., J Immunol 2006
:
Concerning the interaction between CD4 ( + ) T cells and DCs, we tested the hypothesis that CD40 engagement on DCs is critical for
IL-12p70 ( IL-12 ) production and subsequent
stimulation of IFN-gamma release by
CD8 ( + ) T cells
Kosaka et al., Cancer Sci 2006
:
Moreover, ASGM1 ( + )
CD8 ( + ) T cells, but not ASGM1 ( - ) CD8 ( + ) T cells, produced high levels of interferon (IFN)-gamma in
response to
IL-12 plus IL-2
Kilinc et al., J Immunol 2006
(Adenocarcinoma, Bronchiolo-Alveolar...) :
Both
CD8+ T cell activation and T suppressor cell purge were
mediated primarily by
IL-12 and required IFN-gamma
Wells et al., J Allergy Clin Immunol 2007
(Inflammation...) :
Adoptive transfer of transgenic antigen-specific
CD8 , but not CD4, cells
resulted in increased
IL-12 levels and reduced IL-13 and IL-5 levels in bronchoalveolar lavage fluid, coupled with substantially reduced airway eosinophilia after repeated allergen inhalation, a process mimicked by intranasal administration of IL-12 and inhibited by anti-IL-12 antibody
Yang et al., Blood 2007
:
Together, we provide a novel mechanism for T-bet regulation, and suggest that
IL-12/Stat4/T-bet play an important role in
CD8 effector responses
Henry et al., J Immunol 2008
:
IL-12 produced by dendritic cells
augments CD8+ T cell activation through the production of the chemokines CCL1 and CCL17 ... Therefore, we sought to determine the individual
roles of
IL-12 and IL-23 in naive
CD8 ( + ) T cell activation by addressing their ability to influence IFN-gamma production and cellular interaction dynamics during priming by Listeria monocytogenes infected dendritic cells ( DC )
Balkow et al., Exp Dermatol 2009
:
When compared with untreated DC or DC treated with anti-CD40 alone, DC matured with anti-CD40 plus IL-12 and IL-18 expressed significantly more IFN-gamma and
IL-12 ,
induced enhanced
CD8 ( + ) T-cell proliferation, prolonged synaptic interaction with T cells and increased CD8 ( + ) T-cell mediated cytotoxicity
Gozalbo et al., Frontiers in bioscience (Landmark edition) 2009
(Candidiasis) :
IFN-gamma is produced by CD4 Th1,
CD8 , gamma delta T, and natural killer ( NK ) cells, essentially in
response to both
IL-12 and/or IL-18, and plays an important role in the regulation of the immune system as well as in the control of the infectious process
Kaden et al., J Immunol 2009
:
Intriguingly, upon triggering mDCAR1,
CD8 ( + ) DCs
increased the secretion of bioactive
IL-12 , whereas IL-10 release is markedly reduced, thereby indicating that Ag recognized by mDCAR1 induces enhanced proinflammatory responses
Yin et al., Vaccine 2010
(Simian Acquired Immunodeficiency Syndrome) :
We further demonstrated that
interleukin (IL)-12 could significantly
enhance the vaccine specific
CD8 lymphocyte response
Díaz-Montero et al., American journal of cancer research 2011
:
Here we report a simplified combinatorial approach that involves short activation of
CD8 ( + ) T cells in the
presence of
IL-12 followed by adoptive transfer into tumor bearing animals after a single injection of cyclophosphamide
Tamburini et al., J Immunother 2012
:
IL-6 inducing whole yeast based immunotherapy directly controls
IL-12 dependent
CD8 T-cell responses
Sanchez et al., Vaccine 2012
:
We have established a vaccine model system in which the primary
CD8 ( + ) T cell response is
independent of either
IL-12 or type I IFN receptors, but dependent on CD27/CD70 interactions
Dong et al., J Immunol 2012
:
CD27 stimulation promotes the frequency of IL-7 receptor expressing memory precursors and prevents
IL-12 mediated loss of
CD8 ( + ) T cell memory in the absence of CD4 ( + ) T cell help
You et al., Immunobiology 2013
:
In the MLR, DCs from older subjects induced significantly restricted proliferation of young T cells,
activation of
CD8 ( + ) T cells and expression of
IL-12 and IFN-? in T cells compared with young DCs
Stark et al., Eur J Immunol 2013
:
The induction of CD40L in
CD8 ( + ) T cells
regulated by
IL-12 and TCR signaling may enable CD8 ( + ) T cells to respond autonomously of CD4 ( + ) T cells
Maruo et al., J Immunol 1997
:
IL-12 production was
dependent on the presence of CD4+, but not of
CD8+ , T cells, and inhibited by addition of anti-CD40 ligand (CD40L) mAb
Flynn et al., J Exp Med 1998
:
Furthermore, T cell stimulation through OX40 inhibits IFN-gamma expression in both
CD8 T cells and
IL-12 stimulated CD4 T cells