Gene interactions and pathways from curated databases and text-mining

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CAMK4 — GNRH1

Text-mined interactions from Literome

Haisenleder et al., Endocrinology 2003 : GnRH stimulated Ca/CaMK II beta subunit activity 3-fold 2 min after treatment and returned to control values by 45 min ... The Ca/CaMK II response to GnRH was blocked by administration of the Ca/CaMK II-specific inhibitor, KN-93 ... Blocking calcium influx with nimodipine or depleting intracellular calcium storage pools with thapsigargin each resulted in a partial suppression of GnRH induced activation of Ca/CaMK II, and in combination, completely suppressed the Ca/CaMK II response to GnRH
Haisenleder et al., Biol Reprod 2005 : GnRH stimulated a two- to three-fold rise in activated Ca/CaMK II, and E2 and T had no effect on Ca/CaMK II activation