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AFP — EGF

Text-mined interactions from Literome

Keel et al., Endocrinology 1991 : AFP dose-dependently ( 1.25-5 micrograms/ml ) and significantly ( P less than 0.05 ) increased proliferation of porcine granulosa cells in response to platelet derived growth factor ( PDGF ) and EGF ( 25 and 10 ng/ml, respectively ), but not to PDGF alone ... These results demonstrate that physiological levels of AFP , although not mitogenic alone, can significantly enhance the mitogenic activity of EGF plus IGF-I/PDGF and may function to modulate growth factor mediated cell proliferation during development and neoplasia
Kaneko et al., Oncodev Biol Med 1980 (Liver Neoplasms, Experimental) : In a short term cell incubation, TPA and EGF caused an approximately 2-fold increase in the production of alpha-fetoprotein (AFP) and other acid-precipitable materials, while the same concentration of insulin brought a 3-fold increase