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CCNE1 — E2F1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of CCNE1-CDK2 → E2F1 (increases, CCNE1/CDK2 Activity) Hartman et al., Oncogene 2004*
  Evidence: Expression of HES-1 in T47D cells inhibited G(1)/S-phase transition and activation of Cdk2 elicited by estrogen.
• BioCarta cell cycle: g1/s check point: RB/HDAC/ABL/E2F-1/DP-1 complex (E2F1-RB1-TFDP1-ABL1-HDAC1) → Cyclin E/CDK2 complex (CCNE1-CDK2) (modification, collaborate)
  
• BioCarta cell cycle: g1/s check point: Cyclin E/CDK2 complex (CCNE1-CDK2) → E2F-1/DP-1 complex (TFDP1-E2F1) (modification, activates)
  
• BioCarta e2f1 destruction pathway: RB/E2F-1 complex (E2F1-RB1) → Cyclin E/CDK2 complex (CCNE1-CDK2) (modification, collaborate)
  
• BioCarta e2f1 destruction pathway: Cyclin E/CDK2 complex (CCNE1-CDK2) → E2F-1 (E2F1) (modification, activates)
• BioCarta p53 signaling pathway: RB/E2F-1 complex (E2F1-RB1) → CDK2/CYCLIN E/PCNA complex (CDK2-CCNE1-PCNA) (modification, collaborate)
  
• BioCarta regulation of p27 phosphorylation during cell cycle progression: E2F-1/DP-1 complex (TFDP1-E2F1) → Cyclin E (CCNE1) (transcription, activates)
• BioCarta influence of ras and rho proteins on g1 to s transition: RB/E2F-1 complex (E2F1-RB1) → Cyclin E/CDK2 complex (CCNE1-CDK2) (modification, collaborate)
  
• BioCarta cyclins and cell cycle regulation: RB/E2F-1 complex (E2F1-RB1) → Cyclin E/CDK2 complex (CCNE1-CDK2) (modification, collaborate)
  
• BioCarta cell cycle: g1/s check point: E2F-1/DP-1 complex (TFDP1-E2F1) → Cyclin E (CCNE1) (transcription, activates)
• KEGG Cell cycle: Complex of E2F1-E2F2-E2F3-TFDP1-TFDP2 → CCNE1/CCNE2 (gene expression, expression)
• NCI Pathway Database Regulation of retinoblastoma protein: CDK2/Cyclin E1 complex (CDK2-CCNE1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, activates)
  Harbour et al., Cell 1999, Chan et al., Nat Cell Biol 2001, Rubin et al., Cell 2005
  Evidence: mutant phenotype, assay, reporter gene, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CCNE1 — E2F1 (physical association, affinity chromatography technology) Dhillon et al., Oncogene 2002
• IRef Innatedb Interaction: CCNE1 — E2F1 (unknown, -) Masuhiro et al., J Biol Chem 2008*
• IRef Innatedb Interaction: CCNE1 — E2F1 (unknown, -) Cartier et al., J Biol Chem 2011

Text-mined interactions from Literome

Suzuki et al., Int J Cancer 2000 (Mouth Neoplasms...) : TSA enhanced the protein expression of p21 ( WAF1 ), CREB binding protein, cyclinE , cyclin A, Bak and Bax, while it reduced the expression of E2F-1 , E2F-4, HDAC1, p53 and hyperphosphorylated form of Rb
El Messaoudi et al., Proc Natl Acad Sci U S A 2006 : E2F dependent regulation of the CCNE1 promoter was shown to correlate with changes in the level of H3-K9 acetylation/methylation of nucleosomal histones positioned at the transcriptional start site region
Duronio et al., Genes Dev 1995 : Instead, cyclin E expression activates E2F in the CNS
Chiarugi et al., Cell Mol Biol Res 1994 : Notably, both of the two giant regulators of checkpoint 1 ( i.e., p105RB [ retinoblastoma oncosuppressor encoded protein ] and p53 dependent WAF1/CIP1 ) are influenced by or influence G1 cyclins : cyclin E/cdk2 kinase complexes hyperphosphorylate p105RB, induce E2F release, and free G1 exit