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CDKN1A — DCN
Text-mined interactions from Literome
Ständer et al., Cell Tissue Res 1999
(Neoplasms) :
On the other hand, de novo expression of
decorin in colon cancer cells and some other tumor cells, even though not in glioma cells,
results in an upregulation of
p21 expression and a cell cycle arrest, presumably in a TGF-beta independent manner
Schönherr et al., J Biol Chem 2001
:
Reverse transcription-polymerase chain reaction demonstrated that
p21 and p27, two inhibitors of cyclin dependent kinases, were
up-regulated by
decorin induction ...
Decorin also
increased protein levels of
p21 and caused its translocation into the nucleus ... Overexpression of dominant negative Akt inhibited the
decorin mediated induction of
p21 and cyclin A, but had no effect on p27
Santra et al., J Cereb Blood Flow Metab 2006
(Glioma) :
Our data indicate that
induction of
p21 , p27, Ras, AKT, and phosphorylated AKT by
decorin inhibits apoptosis and protects U-87 and SVZ cells against OGD
Li et al., Blood 2008
(Multiple Myeloma...) :
The antimyeloma
effect of
decorin involved direct induction of apoptosis and activation of
p21 ( WAF )
Zafiropoulos et al., Mol Cancer Res 2008
(Osteosarcoma) :
Efforts to determine how MG-63 cells could overcome the decorin induced cytostatic effect established that
decorin in MG-63 cells does not
induce p21 expression nor does it cause protracted retraction and inactivation of the epidermal growth factor receptor
Zafiropoulos et al., Connect Tissue Res 2008
(Neoplasms...) :
Importantly,
decorin did not
induce p21 expression whereas EGFR appeared to be overexpressed and continuously phosphorylated in our osteosarcoma model