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CD4 — TLR9

Text-mined interactions from Literome

Gelman et al., J Immunol 2004 : APC TLR engagement indirectly enhances activated CD4 ( + ) T cell proliferation, differentiation, and survival by promoting the up-regulation of costimulatory molecules and the secretion of proinflammatory cytokines
Castellino et al., J Immunol 2007 : Together, these findings support a model of CD8 ( + ) T cell memory cell differentiation involving the delivery of key signals early in the priming process based on chemokine guided attraction of naive CD8 ( + ) T cells to sites of Ag-driven interactions between TLR activated dendritic cells and CD4 ( + ) T cells
Piconi et al., AIDS 2010 (HIV Infections) : Activated T cells ( Ki67 ( + ) ), Treg lymphocytes ( CD4 ( + ) /CD25high/Foxp3+ ), divided into naive and activated cells based on PD1 expression, interleukin (IL)-10 and transforming growth factor ( TGF ) -beta production, annexin V, activation of caspases 8 and 9, Toll-like receptor (TLR)2 and TLR4 expression on immune cells, and plasma lipopolysaccharide (LPS) concentration were analyzed
Ather et al., J Immunol 2011 (Disease Models, Animal...) : CD4 ( + ) T cells polyclonally stimulated in the presence of conditioned media from SAA exposed DCs produced IL-17, and the capacity of polyclonally stimulated splenocytes to secrete IL-17 is dependent upon IL-1, TLR2 , and the NLRP3 inflammasome
Karrich et al., Blood 2013 : We demonstrate that GrB induction was, in part, responsible for IL-21 mediated downmodulation of CD4 ( + ) T-cell proliferation induced by TLR preactivated pDCs
Rahim et al., J Immunol 2013 (Melanoma, Experimental) : Furthermore, Ly49Q expression on pDC, but not myeloid dendritic cells, is necessary for optimal IL-12 secretion, MHC-II expression, activation of CD4 ( + ) T cell proliferation, and nuclear translocation of the master IFN-a regulator IFN regulatory factor 7 in response to TLR9 agonists
Kader et al., PLoS Pathog 2013 (Simian Acquired Immunodeficiency Syndrome) : TLR7 and TLR9 blockade did not prevent activation of memory CD4+ and CD8+ T cells in blood or lymph node but led to significant increases in proliferation of both subsets in blood following SIV infection