◀ Back to CD4

CD4 — HLA-DRA

Pathways - manually collected, often from reviews:

• BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor: MHC class II complex (HLA-DRA-HLA-DRB1) → CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1) (modification, collaborate)
  
• BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor: MHC class II complex (HLA-DRA-HLA-DRB1) → CD4 (modification, collaborate)
• BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor: CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1) → CD4 (modification, collaborate)
• BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor: CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1) → LCK (modification, collaborate)
• BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor: CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1) → TCR-CD3 complex (CD3Z-TRA@-TRB@-CD3G-CD3E-CD3D) (modification, collaborate)
  
• BioCarta t cell receptor signaling pathway: TCR-CD3/MHC II/CD4/LCK complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK) → ZAP70 (modification, collaborate)
• BioCarta t cell receptor signaling pathway: TCR-CD3/MHC II/CD4/LCK complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK) → TCR-CD3/MHC II/CD4/LCK/ZAP70 complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
  
• BioCarta t cell receptor signaling pathway: ZAP70 → TCR-CD3/MHC II/CD4/LCK/ZAP70 complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
  
• BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor: CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/ZAP70/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-ZAP70-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1) → CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1) (modification, collaborate)
  
• BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor: CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/ZAP70/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-ZAP70-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1) → ZAP70 (modification, collaborate)
• BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor: CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1) → ZAP70 (modification, collaborate)
• BioCarta t cell receptor signaling pathway: TCR-CD3/MHC II/CD4/LCK complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK) → LCK (modification, collaborate)
• BioCarta t cell receptor signaling pathway: TCR-CD3/MHC II/CD4/LCK complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK) → TCR-CD3/MHC II/CD4 complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4) (modification, collaborate)
  
• BioCarta t cell receptor signaling pathway: LCK → TCR-CD3/MHC II/CD4 complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4) (modification, collaborate)
  
• BioCarta t cell receptor signaling pathway: MHC class II complex (HLA-DRA-HLA-DRB1) → TCR-CD3/MHC II/CD4 complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4) (modification, collaborate)
  
• BioCarta t cell receptor signaling pathway: MHC class II complex (HLA-DRA-HLA-DRB1) → CD4 (modification, collaborate)
• BioCarta t cell receptor signaling pathway: TCR-CD3/MHC II/CD4 complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4) → CD4 (modification, collaborate)
• BioCarta t cell receptor signaling pathway: TCR-CD3/MHC II/CD4 complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4) → TCR-CD3 complex (CD3Z-TRA@-TRB@-CD3G-CD3E-CD3D) (modification, collaborate)
  
• KEGG Cell adhesion molecules (CAMs): HLA-DMA/HLA-DMB/HLA-DOA/HLA-DOB/HLA-DPA1/HLA-DPB1/HLA-DQA1/HLA-DQA2/HLA-DQB1/HLA-DRA/HLA-DRB1/HLA-DRB3/HLA-DRB4/HLA-DRB5 → CD4 (protein-protein, activation)
• KEGG Cell adhesion molecules (CAMs): HLA-DMA/HLA-DMB/HLA-DOA/HLA-DOB/HLA-DPA1/HLA-DPB1/HLA-DQA1/HLA-DQA2/HLA-DQB1/HLA-DRA/HLA-DRB1/HLA-DRB3/HLA-DRB4/HLA-DRB5 → CD4 (protein-protein, activation)
• KEGG Antigen processing and presentation: CD4 → HLA-DMA/HLA-DMB/HLA-DOA/HLA-DOB/HLA-DPA1/HLA-DPB1/HLA-DQA1/HLA-DQA2/HLA-DQB1/HLA-DRA/HLA-DRB1/HLA-DRB3/HLA-DRB4/HLA-DRB5 (protein-protein, binding/association)
  
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → PKC theta (PRKCQ) (modification, activates) Liu et al., J Biol Chem 2000, Bi et al., Nat Immunol 2001, Díaz-Flores et al., J Biol Chem 2003, Imboden et al., J Exp Med 1985
  Evidence: mutant phenotype, assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) (modification, activates) Liu et al., J Biol Chem 2000, Bi et al., Nat Immunol 2001, Díaz-Flores et al., J Biol Chem 2003, Imboden et al., J Exp Med 1985
  Evidence: mutant phenotype, assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → B7 family/CD28 complex (CD28-CD80_CD86) (modification, collaborate)
  Pelosi et al., J Biol Chem 1999, Iwashima et al., Science 1994, Chan et al., J Immunol 1994, van Oers et al., J Exp Med 1996, Tuosto et al., Eur J Immunol 1998
  Evidence: mutant phenotype, assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → ZAP-70 (ZAP70) (modification, collaborate) Pelosi et al., J Biol Chem 1999, Iwashima et al., Science 1994, Chan et al., J Immunol 1994, van Oers et al., J Exp Med 1996, Tuosto et al., Eur J Immunol 1998
  Evidence: mutant phenotype, assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
  Pelosi et al., J Biol Chem 1999, Iwashima et al., Science 1994, Chan et al., J Immunol 1994, van Oers et al., J Exp Med 1996, Tuosto et al., Eur J Immunol 1998
  Evidence: mutant phenotype, assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: B7 family/CD28 complex (CD28-CD80_CD86) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, activates)
  Pelosi et al., J Biol Chem 1999, Iwashima et al., Science 1994, Chan et al., J Immunol 1994, van Oers et al., J Exp Med 1996, Tuosto et al., Eur J Immunol 1998
  Evidence: mutant phenotype, assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: ZAP-70 (ZAP70) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
  Pelosi et al., J Biol Chem 1999, Iwashima et al., Science 1994, Chan et al., J Immunol 1994, van Oers et al., J Exp Med 1996, Tuosto et al., Eur J Immunol 1998
  Evidence: mutant phenotype, assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → LAT/GRAP2/SLP76/VAV1 complex (LAT-GRAP2-LCP2-VAV1) (modification, activates)
  Reynolds et al., J Exp Med 2002, Fukazawa et al., J Biol Chem 1995, Exley et al., J Biol Chem 1994, Prasad et al., Mol Cell Biol 1993, Zhang et al., Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → TCR/CD3/MHC II/CD4/LCK/CBL/Ubiquitin complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247-CBL) (modification, collaborate)
  Rao et al., Proc Natl Acad Sci U S A 2002
  Evidence: assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → CBL (CBL) (modification, collaborate) Rao et al., Proc Natl Acad Sci U S A 2002
  Evidence: assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK/CBL/Ubiquitin complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247-CBL) → CBL (CBL) (modification, collaborate) Rao et al., Proc Natl Acad Sci U S A 2002
  Evidence: assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → B7 family/CD28 complex (CD28-CD80_CD86) (modification, activates)
  Woods et al., EMBO J 2001, Wilcox et al., J Biol Chem 2003, August et al., Proc Natl Acad Sci U S A 1994, Raab et al., Proc Natl Acad Sci U S A 1995, Gibson et al., J Biol Chem 1996, Heyeck et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → ITK (ITK) (modification, activates) Woods et al., EMBO J 2001, Wilcox et al., J Biol Chem 2003, August et al., Proc Natl Acad Sci U S A 1994, Raab et al., Proc Natl Acad Sci U S A 1995, Gibson et al., J Biol Chem 1996, Heyeck et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: SHP2 (PTPN11) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, inhibits)
  Kwon et al., EMBO J 2005, Han et al., Science 1998, Michel et al., J Biol Chem 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: Fyn (FYN) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, activates)
  Kwon et al., EMBO J 2005, Han et al., Science 1998, Michel et al., J Biol Chem 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database CXCR4-mediated signaling events: G beta/gamma complex (GNB1-GNG2) → TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) (modification, activates)
  Kumar et al., Immunity 2006, Patrussi et al., Blood 2007
  Evidence: mutant phenotype, assay
• NCI Pathway Database CXCR4-mediated signaling events: G beta/gamma complex (GNB1-GNG2) → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (modification, activates)
  Kumar et al., Immunity 2006, Patrussi et al., Blood 2007
  Evidence: mutant phenotype, assay
• NCI Pathway Database CXCR4-mediated signaling events: Gi family/GTP/RGS1 complex (GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1-RGS1) → TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) (modification, inhibits)
  Kumar et al., Immunity 2006, Patrussi et al., Blood 2007
  Evidence: mutant phenotype, assay
• NCI Pathway Database CXCR4-mediated signaling events: Gi family/GTP/RGS1 complex (GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1-RGS1) → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (modification, inhibits)
  Kumar et al., Immunity 2006, Patrussi et al., Blood 2007
  Evidence: mutant phenotype, assay
• NCI Pathway Database CXCR4-mediated signaling events: LCK (LCK) → TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) (modification, collaborate)
  Kumar et al., Immunity 2006, Patrussi et al., Blood 2007
  Evidence: mutant phenotype, assay
• NCI Pathway Database CXCR4-mediated signaling events: LCK (LCK) → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (modification, collaborate)
  Kumar et al., Immunity 2006, Patrussi et al., Blood 2007
  Evidence: mutant phenotype, assay
• NCI Pathway Database CXCR4-mediated signaling events: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (modification, collaborate)
  Kumar et al., Immunity 2006, Patrussi et al., Blood 2007
  Evidence: mutant phenotype, assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: Fyn (FYN) → TCR/CD3/MHC II/CD4/Fyn complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-FYN-CD247) (modification, collaborate)
  van't Hof et al., J Cell Biol 1999, Samelson et al., Proc Natl Acad Sci U S A 1990
  Evidence: assay, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: Fyn (FYN) → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (modification, collaborate)
  van't Hof et al., J Cell Biol 1999, Samelson et al., Proc Natl Acad Sci U S A 1990
  Evidence: assay, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/Fyn complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-FYN-CD247) → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (modification, collaborate)
  van't Hof et al., J Cell Biol 1999, Samelson et al., Proc Natl Acad Sci U S A 1990
  Evidence: assay, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK/ZAP-70/CBL/SLAP-2/Ubiquitin complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-CBL-SLA2) → CBL (CBL) (modification, collaborate) Wang et al., J Biol Chem 2001, Loreto et al., Mol Cell Biol 2002
  Evidence: assay, physical interaction
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK/ZAP-70/CBL/SLAP-2/Ubiquitin complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-CBL-SLA2) → SLAP-2 (SLA2) (modification, collaborate) Wang et al., J Biol Chem 2001, Loreto et al., Mol Cell Biol 2002
  Evidence: assay, physical interaction
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK/ZAP-70/CBL/SLAP-2/Ubiquitin complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-CBL-SLA2) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
  Wang et al., J Biol Chem 2001, Loreto et al., Mol Cell Biol 2002
  Evidence: assay, physical interaction
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: CBL (CBL) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
  Wang et al., J Biol Chem 2001, Loreto et al., Mol Cell Biol 2002
  Evidence: assay, physical interaction
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: SLAP-2 (SLA2) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
  Wang et al., J Biol Chem 2001, Loreto et al., Mol Cell Biol 2002
  Evidence: assay, physical interaction
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: LAT/GRAP2/SLP76 complex (LAT-GRAP2-LCP2) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
  Liu et al., J Immunol 2000
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: HPK1 (MAP4K1) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
  Liu et al., J Immunol 2000
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: Monovalent TCR/CD3 complex (CD247-CD3E-CD3G-CD3D) → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (modification, collaborate)
  Irvine et al., Nature 2002, Call et al., Cell 2002
  Evidence: assay, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: CD4 (CD4) → peptide/MHC II complex (HLA-DRA-HLA-DRB1) (modification, collaborate)
  Irvine et al., Nature 2002, Call et al., Cell 2002
  Evidence: assay, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: CD4 (CD4) → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (modification, collaborate)
  Irvine et al., Nature 2002, Call et al., Cell 2002
  Evidence: assay, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: peptide/MHC II complex (HLA-DRA-HLA-DRB1) → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (modification, collaborate)
  Irvine et al., Nature 2002, Call et al., Cell 2002
  Evidence: assay, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK/ZAP-70/3BP2 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-SH3BP2) → 3BP2 (SH3BP2) (modification, collaborate) Deckert et al., Immunity 1998
  Evidence: physical interaction
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK/ZAP-70/3BP2 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-SH3BP2) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
  Deckert et al., Immunity 1998
  Evidence: physical interaction
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: 3BP2 (SH3BP2) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
  Deckert et al., Immunity 1998
  Evidence: physical interaction
• NCI Pathway Database IL12 signaling mediated by STAT4: T-bet (TBX21) → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (transcription, activates)
  Szabo et al., Science 2002, Wittmann et al., J Leukoc Biol 2006
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database IL12 signaling mediated by STAT4: Calcineurin A alpha-beta B1 () → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (transcription, inhibits)
  Szabo et al., Science 2002, Wittmann et al., J Leukoc Biol 2006
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database IL12 signaling mediated by STAT4: STAT4 (dimer) complex (STAT4) → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (transcription, activates)
  Szabo et al., Science 2002, Wittmann et al., J Leukoc Biol 2006
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: CSK/PAG1 complex (CSK-PAG1) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
  Brdicka et al., J Exp Med 2000
  Evidence: assay, physical interaction
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: SHP1 (PTPN6) → TCR/CD3/MHC II/CD4/LCK/ZAP-70/3BP2 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-SH3BP2) (modification, activates)
  Yu et al., FEBS J 2006
  Evidence: mutant phenotype
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → LCK (LCK) (modification, collaborate) Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Kersh et al., Science 1998, Tuosto et al., Eur J Immunol 1998, Viola et al., Science 1999
  Evidence: mutant phenotype, assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (modification, collaborate)
  Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Kersh et al., Science 1998, Tuosto et al., Eur J Immunol 1998, Viola et al., Science 1999
  Evidence: mutant phenotype, assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: B7 family/CD28 complex (CD28-CD80_CD86) → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (modification, activates)
  Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Kersh et al., Science 1998, Tuosto et al., Eur J Immunol 1998, Viola et al., Science 1999
  Evidence: mutant phenotype, assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: LCK (LCK) → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (modification, collaborate)
  Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Kersh et al., Science 1998, Tuosto et al., Eur J Immunol 1998, Viola et al., Science 1999
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL12-mediated signaling events: Calcineurin A alpha-beta B1 () → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (transcription, inhibits)
  Wittmann et al., J Leukoc Biol 2006
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL12-mediated signaling events: IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2) → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (transcription, activates)
  Wittmann et al., J Leukoc Biol 2006
  Evidence: mutant phenotype, assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK/ZAP-70/3BP2 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-SH3BP2) → None (modification, activates) Deckert et al., Immunity 1998
  Evidence: reporter gene
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: ITK (ITK) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, activates)
  Paz et al., Biochem J 2001, Perez-Villar et al., Biochemistry 2002, Zhang et al., Cell 1998
  Evidence: assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: SHP2 (PTPN11) → TCR/CD3/MHC II/CD4/Fyn complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-FYN-CD247) (modification, inhibits)
  Kwon et al., EMBO J 2005, da Silva et al., Proc Natl Acad Sci U S A 1997
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → B7 family/CD28 complex (CD28-CD80_CD86) (modification, activates)
  Raab et al., Proc Natl Acad Sci U S A 1995
  Evidence: mutant phenotype, assay
• Reactome Reaction: CD4 → HLA-DRA (indirect_complex) Leo et al., J Clin Invest 2002, Huang et al., J Biol Chem 2004, Boggon et al., Oncogene 2004, Palacios et al., Oncogene 2004, Wilkinson et al., Expert reviews in molecular medicine 2005
• Reactome Reaction: CD4 → HLA-DRA (reaction) Huang et al., J Biol Chem 2004, Palacios et al., Oncogene 2004, Wilkinson et al., Expert reviews in molecular medicine 2005, van Oers et al., Semin Immunol 1995, Chu et al., Immunol Rev 1998

Text-mined interactions from Literome

Bartnes et al., Immunology 2000 (Lymphoma, B-Cell...) : Immunoglobulin peptide/MHC class II complexes may also be involved in autoimmunity and CD4+ T-cell mediated B-cell regulation
Zhou et al., Cell Signal 2003 (Calcium Signaling) : T cell receptor independent CD4 signalling : CD4-MHC class II interactions regulate intracellular calcium and cyclic AMP
Carbonneil et al., Int Immunol 2004 : In addition, neutralization of IL-10 during the differentiation of DCs increased the expression of DC-LAMP and MHC class II by IFN-DCs, and the ability of IFN-DCs to stimulate allogeneic CD4 ( + ) T-cell proliferation at similar levels, than IL-4-DCs
Chakraverty et al., Blood 2006 : CD8 ( + ) T-cell dependent GVL responses against an MHC class II-negative tumor following delayed DLI require CD4 ( + ) T-cell help and are reduced significantly when host APCs lack MHC class II expression
Dong et al., PloS one 2013 : The dendritic cell-driven Qa2 induction of CD4 ( + ) pre-RTEs is independent of MHC class II and Aire molecules