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AHR — CD4

Text-mined interactions from Literome

Borchers et al., Am J Physiol Lung Cell Mol Physiol 2001 (Bronchial Hyperreactivity...) : Intrinsic AHR in IL-5 transgenic mice is dependent on CD4 ( + ) cells and CD49d mediated signaling ... These studies demonstrate that, despite the presence of increased levels of IL-5 and eosinophils in the lungs of NJ.1726 mice, CD4 ( + ) cells and alpha ( 4 ) -integrin signaling are necessary for the intrinsic AHR that develops in IL-5 transgenic mice
Leigh et al., J Appl Physiol 2004 (Bronchial Hyperreactivity...) : We have described a mouse model in which chronic allergen exposure results in sustained AHR and aspects of airway remodeling and here sought to determine whether eliminating CD4 ( + ) and CD8 ( + ) cells, at a time when airway remodeling had occurred, would attenuate this sustained AHR
Joetham et al., J Immunol 2007 (Hypersensitivity...) : Significantly, CD4 ( + ) CD25 ( + ) T cells isolated from IL-10 ( -/- ) mice had no effect on AHR and inflammation, but when incubated with rIL-10 before transfer, suppressed AHR , and inflammation, and was associated with elevated levels of bronchoalveolar lavage TGF-beta levels
Joetham et al., Proc Natl Acad Sci U S A 2007 (Hypersensitivity...) : Naturally occurring Foxp3 ( + ) CD4 ( + ) CD25 ( + ) T cells ( nTregs ) isolated from lungs of naive mice regulate allergic airway hyperresponsiveness (AHR) and inflammation
Kolli et al., J Virol 2008 (Disease Models, Animal...) : Concurrent depletion of CD4 ( + ) and CD8 ( + ) T cells completely blocked airway obstruction as well as AHR
Kerkvliet et al., Biochem Pharmacol 2009 : With TCDD, most adaptive immune responses are highly suppressed, which has been recently linked to the AHR dependent induction of CD4 ( + ) CD25 ( + ) regulatory T cells
Pot et al., Schweiz Med Wochenschr 2012 (Autoimmune Diseases) : Aryl hydrocarbon receptor controls regulatory CD4+ T cell function