Murillo et al., Clin Cancer Res 2008
(Disease Models, Animal...) :
Antitumor efficacy of anti-CD137 mAb was preserved in CD28-deficient mice despite the fact that CD28 signaling increases the expression of CD137 on CD8 ( + ) T cells
Habib-Agahi et al., Cell Immunol 2009
:
These findings show a positive effect of CD137 signalling on CD28 expression, similar to the effect of CD28 engagement on 4-1BB expression during the initial phases of T cell activation