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CD28 — MAPK7
Text-mined interactions from Literome
Zhang et al., J Immunol 1999
:
In contrast to that reported for human Jurkat T cells, we found that p38
MAPK , but not Jun NH2-terminal kinase (JNK), is weakly activated upon
stimulation with either anti-CD3 or
anti-CD28 in murine thymocytes and splenic T cells ... However, p38
MAPK is
activated strongly and synergistically by either
CD3/CD28 coligation or PMA/Ca2+ ionophore stimulation, which mimics TCR-CD3/CD28 mediated signaling
Marti et al., J Immunol 2001
:
TCR and
CD28 costimulatory receptor-cooperative induction of T cell IL-2 secretion is
dependent upon activation of
mitogen activated protein ( MAP ) kinases
Yu et al., J Immunol 2001
(MAP Kinase Signaling System) :
Notably,
CD28 ligation
activated p38
MAPK and CaMKIV, the kinases stimulated by CD3 engagement, suggesting that CD28 acts by increasing the activation extent of p38 MAPK and CaMKIV