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IRF6 — VDR

Text-mined interactions from Literome

Pramanik et al., Cell Immunol 2004 : The biologically active form of vitamin D3, 1alpha,25-dihydroxy vitamin D3 [ 1,25 ( OH ) 2D3 ], induced VDR in THP-1 cells after 24 h treatment, and LPS inhibited 1,25 ( OH ) 2D3 mediated VDR induction ... Although the proteasome pathway plays an important role in VDR degradation, the proteasome inhibitor lactacystin had no effect on the LPS mediated down-regulation of 1,25 ( OH ) 2D3 induced VDR levels ... The above results suggest that LPS impairs 1,25 ( OH ) 2D3/VDR functions, which may negatively affect the ability of 1,25 ( OH ) 2D3 to induce myeloid differentiation into monocytes/macrophages
Brosbøl-Ravnborg et al., Clin Dev Immunol 2013 : Both LPS and PGN enhanced the level of the vitamin D3 receptor (VDR)