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Dehoux et al., FEBS Lett 2003
(Body Weight) :
LPS ( 750 microg/100 g body weight )
induces MafBx and Murf mRNA ( respectively, 23-fold and 33-fold after 12 h ; P < 0.001 ) ... In summary,
MafBx and Murf mRNA are up-regulated in
response to
LPS and might play a role in the muscle proteolysis observed
Jin et al., J Cell Biochem 2007
(Muscular Atrophy) :
Daily intraperitoneal ( i.p. ) injection of curcumin ( 10-60 micro g/kg ) for 4 days inhibited, in a dose dependent manner, the
LPS stimulated ( 1 mg/kg, i.p. ) increase of
atrogin-1/MAFbx expression in gastrocnemius and extensor digitorum longus (EDL) muscles, resulting in the attenuation of muscle protein loss
Crossland et al., J Physiol 2010
(Disease Models, Animal...) :
However, Dex did not prevent the
LPS mediated
increase in
muscle atrophy F-box (MAFbx) and muscle RING finger 1 (MuRF1) mRNA expression, but did significantly reduce the LPS mediated increase in cathepsin-L mRNA expression and enzyme activity by 43 % ( P < 0.001 ) and 53 % ( P < 0.05 ), respectively
Martin et al., J Physiol Pharmacol 2012
:
Both types of meloxicam treatment blocked
LPS induced increase in
atrogin-1