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TNF — UGCG
Text-mined interactions from Literome
Nyhlén et al., Cytokine 2000
:
IFN-gamma as well as the
GCs , Dexamethasone and Budesonide,
inhibited TNF-alpha induced IL-8 secretion in a dose dependent manner
Rahman et al., Biochem Pharmacol 2000
(Lung Diseases) :
TNF-alpha also
induces the activation of NF-kappa B and AP-1 and the subsequent increase in
gamma-GCS heavy subunit transcription in these cells
Miller-Larsson et al., Am J Respir Crit Care Med 2000
:
Instilled 1 h before LPS, both
GCs reduced
TNF-alpha by 70 % ( p < 0.05 ) and mononuclear cells by 55 % ( p < 0.01 ), with no reduction in neutrophils
Chen et al., Int Immunopharmacol 2003
(Arthritis, Experimental...) :
At the same time,
GCS inhibited mRNA expression of G ( i, ) and
TNF-alpha of synoviocytes and increased mRNA expression of G ( s ) of synoviocytes in CIA rats
Thorn et al., Scand J Immunol 2004
:
The
TNF-driven induction of SAA1, but not that of SAA2, can be
enhanced by
GCs in both cell lines, whereas GCs alone can upregulate SAA1 only in epithelial cells
Tiitto et al., Hum Pathol 2004
(Lung Diseases, Interstitial) :
We investigated the
regulation of
gamma-GCS by transforming growth factor beta(1) ( TGF-beta(1) ) and
tumor necrosis factor alpha (TNF-alpha) in human lung cells and its expression and distribution in fibrotic ( biopsy-proven idiopathic pulmonary fibrosis, for instance, usual interstitial pneumonia, UIP, n = 15 ), inflammatory, and granulomatous diseases of human lung parenchyma ( desquamative interstitial pneumonia, n = 10 ; ILD associated with collagen diseases, n = 10 ; sarcoidosis, n = 19 and allergic alveolitis, n = 8 )
Elenkov et al., Ann N Y Acad Sci 2004
(Immune System Diseases...) :
Evidence accumulated over the last 5-10 years indicates that
glucocorticoids (GCs) inhibit the production of interleukin (IL)-12, interferon (IFN)-gamma, IFN-alpha, and
tumor necrosis factor (TNF)-alpha by antigen presenting cells (APCs) and T helper ( Th ) 1 cells, but upregulate the production of IL-4, IL-10, and IL-13 by Th2 cells
Stricklett et al., J Infect Dis 2005
:
SB203580, a specific inhibitor of p38 MAPK, reduced TNF stimulated Stx cytotoxicity in HBECs, TNF stimulated ( 125 ) Stx-1 binding to intact HBECs, the cellular content of Gb3 ( galactose alpha 1,4, galactose ss 1,4, glucose-ceramide ) ( the Stx receptor ), and
TNF stimulated Gb3 synthase and
glucosylceramide synthase activities but did not affect lactosylceramide synthase activities or mRNA content
Urata et al., J Biol Chem 1996
(Diabetes Mellitus...) :
The addition of inhibitors for nuclear factor kappaB (NF-kappaB) to the cells caused a loss of the
gamma-GCS mRNA expression in
response to
TNF-alpha ... In summary, the expression of
gamma-GCS is
regulated by
TNF-alpha or IL-1beta in endothelial cells mediated by NF-kappaB stimulation, and impairment of the regulation of gamma-GCS in hyperglycemic cells may be a cause of medical complications that develop in diabetes mellitus
Morales et al., J Biol Chem 1997
:
Furthermore, intact nuclei isolated from hepatocytes treated with TNF transcribed the gamma-GCS-HS gene to a greater extent than control cells, indicating that
TNF regulates
gamma-GCS-HS at the transcriptional level ... The capacity to synthesize GSH de novo determined in cell-free extracts incubated with GSH precursors was greater ( 50-70 % ) in hepatocytes that were treated with TNF ; however, the activity of GSH synthetase remained unaltered by TNF treatment indicating that
TNF selectively
increased the activity of
gamma-GCS ... Despite activation of nuclear factor-kappaB (NF-kappaB) by TNF, this transcription factor was not required for
TNF induced transcription of
gamma-GCS-HS as revealed by deletion constructs of the gamma-GCS-HS promoter subcloned in a chloramphenicol acetyltransferase reporter vector and transfected into HepG2 cells