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PLAU — TNF

Text-mined interactions from Literome

Solomon et al., Invest Ophthalmol Vis Sci 2000 (Pterygium) : Both IL-1beta and TNF-alpha induced a significant decrease in uPA expression in PBF, whereas bFGF induced a slight increase in both HJF and PBF
Feliciani et al., Exp Dermatol 2003 (Acantholysis...) : Our results confirm the role of uPA in acantholysis and suggest an involvement of IL-1alpha/TNF-alpha in uPA induction
Gyetko et al., J Leukoc Biol 1992 : Immunoreactive uPA was induced equally by IFN and TNF , but TNF generated higher levels of PAI-2
Iwamoto et al., Dig Dis Sci 2003 (Stomach Ulcer) : To clarify the role of human gastric fibroblasts in acute inflammatory conditions such as gastric ulcer, the effects of interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha on the expression of uPA and uPAR, which were suggested to be associated with tissue remodeling, in gastric fibroblasts were investigated
Niedbala et al., Biomed Biochim Acta 1991 : The induction of uPA by TNF was inhibited by actinomycin D and cycloheximide implying the necessity of RNA and protein synthesis, respectively
Novak et al., Nucleic Acids Res 1991 : Our results suggest that maximal transcriptional activation of the uPA gene by PMA, IL-1 and TNF alpha requires the induction of NFkB activity and the decay of a short lived repressor protein, possibly IkB
Narita et al., J Oral Sci 2012 : In the presence of another inflammatory cytokine, interleukin 1ß ( IL-1ß, 100 pg/mL ), TNF-a stimulated expression of uPA mRNA and secretion of uPA were enhanced
Falcone et al., J Cell Physiol 1993 : When examined at similar concentrations, bFGF had little effect, and interleukin-1 alpha, tumor necrosis factor-alpha , and monocyte colony stimulating factor had no effect on macrophage uPA expression
Gerritsen et al., Blood Cells 1993 (Arthritis, Rheumatoid...) : TNF alpha treatment of human umbilical vein endothelial ( HUVE ) cells induced urokinase-type plasminogen (uPA) activity, increased HUVE uPA dependent extracellular matrix ( ECM ) degradation, and accelerated matrix remodeling and endothelial differentiation into tubes or cord-like structures
Egawa et al., Experientia 1994 : Effect of radical scavengers on TNF alpha mediated activation of the uPA in cultured cells ... PDTC, on the other hand, did not affect the induction of the uPA gene by TNF alpha ... These results suggest that intracellular glutathione level rather than the oxidation state is necessary for the induction of the uPA gene by TNF alpha
Shetty et al., Am J Respir Cell Mol Biol 1996 (Pulmonary Fibrosis) : Phorbol myristate acetate, lipopolysaccharide, transforming growth factor-beta ( TGF-beta ), and tumor necrosis factor-alpha (TNF-alpha) increased uPA binding and plasminogen activation at the cell surface, with a greater maximal effect on fibrotic than on normal fibroblasts
Niiya et al., Thromb Haemost 1995 (Lymphoma, B-Cell...) : Recombinant IL-1 alpha, recombinant IL-1 beta and LPS but not recombinant IL-6, recombinant TNF alpha and TGF beta dose-dependently increased uPA accumulation in the conditioned medium
Guerrini et al., FEBS Lett 1996 : Using the protein synthesis inhibitor cycloheximide and the antioxidant PDTC, that have an opposite effect on NF-kappa B and AP-1 activation, we showed that uPA mRNA induction by TNF-alpha and PMA in the A549 cell line is mainly due to NF-kappa B activation
Kobayashi et al., Eur J Cell Biol 1996 : TNF can promote the production of uPA in HUVEC and in U937 cells ... The PKC inhibitors ( H7, calphostin C, and staurosporine ) inhibited TNF induced uPA expression and secretion in a dose dependent manner ... Analysis of the expression of cell surface receptor bound uPA by flow cytometry using uPA-specific MAb indicates that induction of uPA expression by TNF was inhibited when these cells were incubated with UTI
Kobayashi et al., Int J Oncol 1998 : We conclude that UTI suppresses tumor cell invasion and metastasis by a mechanism that UTI inhibits TNF stimulated uPA production via a PKC dependent mechanism
Takahashi et al., Am J Physiol 1998 (Hemangioma) : The secretion of uPA and plasminogen activator inhibitor-1 from HLMECs was also enhanced by tumor necrosis factor-alpha and IL-2