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TGFB1 — TYR

Text-mined interactions from Literome

Martínez-Esparza et al., Int J Biochem Cell Biol 2001 (Hypopigmentation...) : Transforming growth factor-beta1 ( TGFbeta1 ) downregulates tyrosinase in B16 melanoma cells by decreasing gene expression and the intracellular half-life of the enzyme, but does not block tyrosinase stimulation by alpha-melanocyte stimulating hormone ( alphaMSH )
Xu et al., Biochem Biophys Res Commun 2003 (Carcinoma, Hepatocellular...) : TGF-beta1 could also enhance FAK-Tyr phosphorylation
Kim et al., Int J Biochem Cell Biol 2004 (MAP Kinase Signaling System) : Our results show that TGF-beta1 significantly inhibits melanin synthesis in a concentration dependent manner and that it reduces the activity of tyrosinase , the rate limiting melanogenic enzyme ... PD98059 was also found to abrogate the TGF-beta1 mediated down-regulation of MITF, tyrosinase , TRP-1, and TRP-2 production