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RAC1 — SLC2A4RG

Text-mined interactions from Literome

Takuwa et al., Biochim Biophys Acta 2002 : Edg5 mediated Rac inhibition involves stimulation of Rac-GTPase activating protein (GAP) activity, rather than inhibition of Rac-guanine nucleotide exchange factor (GEF) activity
Buchsbaum et al., J Biol Chem 2003 : Tiam1 is a ubiquitous guanine nucleotide exchange factor (GEF) that activates the Rac GTPase
Debreceni et al., J Biol Chem 2004 : The N1406A/D1407A mutant of Trio acted dominant negatively in vitro by retaining Rac1 binding activity but losing GEF catalytic activity and competitively inhibited Rac1 activation by wild type Trio
Gao et al., Proc Natl Acad Sci U S A 2004 (Prostatic Neoplasms) : In vitro it could effectively inhibit Rac1 binding and activation by the Rac-specific GEF Trio or Tiam1 in a dose dependent manner without interfering with the closely related Cdc42 or RhoA binding or activation by their respective GEFs or with Rac1 interaction with BcrGAP or effector PAK1
Lu et al., Nature structural & molecular biology 2004 : These data reveal a new mode of action of PH domains and a novel, evolutionarily conserved mechanism by which a bipartite GEF can activate Rac
Mizrahi et al., J Biol Chem 2005 : 7 ) Free GDP is derived exclusively by dissociation from prenylated Rac1-GDP , mediated by GEF
Fernandez-Zapico et al., Cancer Cell 2005 (Adenocarcinoma...) : Mechanistically, the effects of Vav1 require its GEF activity and the activation of Rac1 , PAK1, and NF-kappaB and involve cyclin D1 upregulation
Sato et al., Cancer Sci 2005 : The activation of Cdc42 and Rac by the trans-interaction of nectin and nectin is mediated by c-Src, another small G protein, Rap1, a Cdc42-GEF , FRG, and a Rac-GEF, Vav2
Santy et al., Curr Biol 2005 : We report here that ARNO dependent activation of Rac is mediated by a bipartite Rac GEF , the Dock180/Elmo complex
Strumane et al., Methods Enzymol 2006 (Skin Neoplasms) : The Tiam1 gene encodes a guanine nucleotide exchange factor (GEF) that specifically activates the Rho-like GTPase Rac
Mohl et al., Naunyn Schmiedebergs Arch Pharmacol 2006 : As detected by guanine nucleotide exchange activity assay, precipitation assay of GTP bound Rho proteins and serum response element dependent gene transcription Gef10 activates RhoA-C, but not Rac1 or Cdc42
Itoh et al., J Cell Sci 2008 : Because knockdown of these GEFs suppressed EGF induced Rac1 activation only partially, we looked for another Rac1 GEF downstream of the EGF receptor and found that Asef, a Rac1-Cdc42 GEF bound to the tumor suppressor APC, also contributed to EGF induced Rac1 activation
Bulgin et al., Infect Immun 2010 : The Salmonella effector SopE is a guanine nucleotide exchange factor (GEF) that activates Rac1 and Cdc42, which induce `` the trigger mechanism of cell entry. ''
Bach et al., Mol Biol Cell 2010 : M-cadherin dependent pathways that signal through Rac1 GTPase activation via the Rho-guanine nucleotide exchange factor ( GEF ) Trio are important for myoblast fusion
Chen et al., Proc Natl Acad Sci U S A 2011 : In cultured mammalian cells, RAC1 is activated by increased TRIO 's GEF activity when DISC1 is present ... In cultured mammalian cells, RAC1 is activated by increased TRIO 's GEF activity when DISC1 is present
Ladhani et al., Neoplasia (New York, N.Y.) 2011 (Neoplasm Invasiveness...) : These changes in cell shape depended on decreased RhoA and increased Rac1 activation and were mediated by the up-regulation of Rac1-GEF , DOCK3 and down-regulation of Rac1-GAP, ARHGAP22
Solinet et al., Histochem Cell Biol 2011 (MAP Kinase Signaling System) : Here, we show that MHCIIB-deficient fibroblasts are characterized by a sustained guanine nucleotide exchange factor (GEF) dependent activation of the small GTPase Rac-1 that is responsible for the continual lamellipodium formation ... Moreover, we observed a sustained PKC-? activation and an increased association of cortactin with the plasma membrane in the MHCIIB ( -/- ) cells that were also dependent on GEF mediated Rac-1 activation
Iyer et al., PloS one 2012 : Moreover, overexpression studies demonstrate that Trio acts to promote higher order dendritic branching, including the formation of dendritic filopodia, through Trio GEF1 dependent interactions with Rac1 , whereas Trio GEF-2 dependent interactions with Rho1 serve to restrict dendritic extension and higher order branching in da neurons