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RAC1 — RNF19A

Text-mined interactions from Literome

Lee et al., J Biol Chem 2001 : This betaPix induced p38 activation was blocked by coexpression of dominant negative Cdc42/Rac or kinase-inactive PAK, indicating that the effect of betaPix on p38 is exerted through the Cdc42/Rac-PAK pathway and requires PAK kinase activity
Platanias et al., Pharmacol Ther 2003 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : p38 is rapidly activated during engagement of the Type I IFN receptor, and such an activation is regulated by the small G-protein Rac1 , which functions as its upstream effector in a tyrosine kinase dependent manner
Hammarberg et al., Biochem Pharmacol 2004 : In addition, inhibition of Rac/Cdc42 , small GTPases of the Rho family, by clostridium toxin B, diminished p38 phosphorylation but did not affect ERK1/2
Qu et al., J Biochem 2005 (Diabetes Mellitus, Experimental...) : FcepsilonRI mediated tyrosine phosphorylation of Syk, Gab2, and phospholipase C-gamma1, and activation of c-Jun N-terminal kinase (JNK), extracellular signal regulated kinase ( ERK ), p38 mitogen activated protein kinase ( MAP kinase ), and inhibitor of nuclear factor kappaB kinase ( IKK ), and generation of Rac1 are unaffected in cells overexpressing the truncated Cbl-b in the lipid raft
Hashimoto et al., J Exp Med 1998 : JNK response is dependent on Rac1 and calcium mobilization, whereas p38 response requires Rac1 and PKC activation