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Text-mined interactions from Literome
Zhang et al., J Virol 2003
:
Here, we show that IE1-72 can alleviate
p107 inhibition of
cyclin E/cdk2 kinase activity ... In addition, these two IE1-72 mutants did not alleviate
p107 inhibition of
cyclin E/cdk2 kinase activity and also failed to alleviate p107 inhibition of the E2F-responsive promoter ... Meanwhile, deletion of the N-terminal aa 1 to 175 of p107 abolished both p107 binding with IE1-72 and
p107 inhibition of
cyclin E/cdk2 kinase activity
Pilkinton et al., Oncogene 2007
:
Importantly, the repressor complex that Mip/LIN-9 forms with p107 takes functional precedence over the transcriptional activation linked to the Mip/LIN-9 and B-Myb interaction since expression of
p107 blocks the activation of the
cyclin B promoter triggered by B-Myb and Mip/LIN-9
Poplawski et al., Thyroid research 2008
:
p107 and p130
inhibits activity of
cyclin/cdk2 complexes
Zerfass et al., J Virol 1996
:
This indicates that activation of
cyclin A gene expression
requires the binding of E1A to
p107 , while binding to either pRB or p300 is not involved in transcriptional activation ... We demonstrate that
p107 represses the
cyclin A promoter through its cell cycle-regulatory E2F binding site and that 12S E1A can activate the cyclin A promoter, essentially by counteracting its repression by p107
Dimri et al., Mol Cell Biol 1996
:
Moreover, p21 protein ( wild type but not mutant ) specifically disrupted an
E2F-cyclin dependent protein kinase
2-p107 DNA binding complex in nuclear extracts of proliferating cells, whether or not they expressed normal pRb