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ESR2 — NOS3

Text-mined interactions from Literome

Simoncini et al., J Clin Endocrinol Metab 2000 : Indeed, raloxifene induced NO production is due to an estrogen receptor dependent acute stimulation of eNOS enzymatic activity
Nuedling et al., FEBS Lett 2001 : To define the role of ERbeta in the transcriptional activation of both endothelial ( eNOS ) and inducible nitric oxide synthase (iNOS) in cardiac myocytes, we used the complete ER-specific antagonist R, R-tetrahydrochrysene ( R, R-THC ) ... Taken together, these results show that ERbeta mediates transcriptional activation of eNOS and iNOS by E2
Zhu et al., Science 2002 (Hypertension) : In wild-type mouse blood vessels, estrogen attenuates vasoconstriction by an ERbeta mediated increase in inducible nitric oxide synthase expression
Chambliss et al., Mol Endocrinol 2002 : A subpopulation of ERbeta was localized to the endothelial cell plasma membrane, overexpression of ERbeta enhanced rapid eNOS stimulation by E2, and the response to endogenous ER activation was inhibited by the ERbeta-selective antagonist RR-tetrahydrochrysene (THC) ... eNOS activation through ERbeta was reconstituted and shown to occur independent of ERalpha in COS-7 cells, and ERbeta protein in COS-7 was directed to the plasma membrane
Simoncini et al., Arterioscler Thromb Vasc Biol 2003 : By interacting with phosphatidylinositol 3-kinase (PI3K), estrogen receptor (ER) alpha leads to activation of protein kinase Akt and to subsequent increase in endothelial nitric oxide synthase activity
Kakui et al., Mol Hum Reprod 2004 : These data suggest the possibility that both ERalpha and ERbeta are involved in the estrogen associated regulation of eNOS gene expression in the human myometrium
Xia et al., Endocrinology 2004 (Neuroblastoma) : These results demonstrate that E2-stimulated NO production occurs via estrogen receptor mediated activation of the constitutive NOSs, neuronal NOS and eNOS
Gingerich et al., Endocrinology 2005 : Using the ERbeta agonist, genistein ( 0.1 microm ), we determined that activation of ERbeta induces increased eNOS expression and a decreased number of nNOS positive neurons
Cignarella et al., J Pharmacol Exp Ther 2009 (Diabetes Mellitus, Experimental...) : Distinct roles of estrogen receptor-alpha and beta in the modulation of vascular inducible nitric-oxide synthase in diabetes
Hwang et al., Toxicol Appl Pharmacol 2011 : Puerarin induced eNOS phosphorylation required estrogen receptor ( ER ) -mediated phosphatidylinositol 3-kinase (PI3K)/Akt signaling and was reversed by AMP activated protein kinase (AMPK) and calcium/calmodulin dependent kinase II ( CaMKII ) inhibition