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IL6 — TIMP3

Text-mined interactions from Literome

Wu et al., Am J Pathol 2012 (Adenocarcinoma...) : Mechanistic studies indicated that TIMP-3 loss promoted interleukin-6 (IL-6) production, which led to cell invasion and anchorage independent growth on soft agar plates ... In summary, loss of TIMP-3 may increase IL-6 production via the tumor necrosis factor a/nuclear factor ?B axis, thereby promoting tumor malignancy and subsequent relapse and poor survival in patients with HPV infected non-small cell lung cancer
Gatsios et al., Eur J Biochem 1996 : Interleukin-6 itself had no effect on synovial lining cells but a complex of interleukin-6 and the soluble interleukin-6 receptor induced activation of signal transducer and activator of transcription ( STAT ) factors in these cells and regulated TIMP-1 and TIMP-3 expression in a similar fashion as oncostatin M