Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
PRKD1
→
IL6
(increases, IL6 Activity)
Evidence: Growth factors and cytokines within the BM microenvironment (ie, IL-6 and VEGF) mediate MM-cell growth, survival, and drug resistance....enzastaurin inhibited PKCu/PKD activation triggered by these stimuli...Furthermore, serum isolated from MM patient BM strongly triggered Thr-514 phosphorylation as well as activation of downstream signaling molecules including MARCKS, JNK, and c-Myc...enzastaurin strongly inhibited seruminduced phosphorylation of catalytic Thr-514 PKC and downstream signaling m...
OpenBEL Selventa BEL large corpus:
PRKD1
→
IL6
(increases, IL6 Activity)
Evidence: Taken together, these data confirm that enzastaurin inhibits PKC activation triggered by BMSC-secreted growth factors and cytokines, costimulation with the extracellular matrix protein fibronectin, VEGF or IL-6, as well as MM patient serum.