Riedemann et al., J Immunol 2003
(Sepsis) :
Our previous work has suggested a role for IL-6 in the up-regulation of C5aR in sepsis ... These data suggest that IL-6 plays an important role in the increased expression of C5aR in lung, liver, kidney, and heart during the development of sepsis in mice and that interception of IL-6 leads to reduced expression of C5aR and improved survival
Schlaf et al., Histol Histopathol 2003
(Inflammation) :
Interleukin-6 (IL-6) as a main inflammatory mediator in the liver induced a de novo expression of functional C5aR in HC in-vitro and in-vivo
Tu et al., Blood 2010
:
In addition to C3 receptors, C3aR/C5aR also regulate OC differentiation, at least in part, by modulating local IL-6 production