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FASLG — IL18

Text-mined interactions from Literome

Hashimoto et al., J Immunol 1999 (Melanoma) : Since IL-18 enhances Fas ligand (FasL) expression on NK cell lines, the IL-18 antitumor effects could be mediated by FasL induced cross linking of Fas and subsequent tumor apoptosis
Tsutsui et al., Immunity 1999 (Liver Diseases) : Caspase-1 independent, Fas/Fas ligand mediated IL-18 secretion from macrophages causes acute liver injury in mice ... Administration of Propionibacterium acnes ( P. acnes ) upregulated functional Fas expression on macrophages in an IFNgamma dependent manner, and these macrophages became competent to secrete mature IL-18 upon stimulation with FasL
Dinarello et al., Methods 1999 (Infection...) : IL-18 induces gene expression and synthesis of tumor necrosis factor (TNF), IL-1, Fas ligand , and several chemokines
Urushihara et al., J Pediatr Surg 2000 (Biliary Atresia) : In addition, IL-18 enhances intracellular adhesion molecule-1 ( ICAM-1 ) expression as well as Fas ligand (FasL) expression, and induces apoptosis in hepatic injury
Leite-de-Moraes et al., J Immunol 2000 : This process was preceded by up-regulation of Fas ( CD95 ) and Fas ligand expression in response to IL-12 plus IL-18 and was blocked by zVAD, a large spectrum caspase inhibitor, as well as by anti-Fas ligand mAb, suggesting the involvement of the Fas pathway
Okano et al., Anticancer Res 2000 (Carcinoma...) : Canine interleukin-18 induces apoptosis and enhances Fas ligand mRNA expression in a canine carcinoma cell line
Itoi et al., Blood 2001 (Acute Disease...) : Fas ligand induced caspase-1 dependent accumulation of interleukin-18 in mice with acute graft-versus-host disease ... In contrast, recipients having transplantation with gld/gld spleen cells, which lack functional Fas ligand (FasL), contained only normal ranges of IL-18, indicating FasL mediated IL-18 release in aGVHD ... These results suggest FasL mediated caspase-1 dependent IL-18 secretion in aGVHD in mice
Muneta et al., J Interferon Cytokine Res 2001 : Furthermore, the mRNA expression of porcine FasL in porcine peripheral blood lymphocytes ( PBL ) was induced by porcine interleukin-18 (IL-18)
Ohshima et al., Leukemia & lymphoma 2002 (Histiocytic Necrotizing Lymphadenitis) : The CXC chemokine interferon-gamma-inducible protein-10 ( IP-10 ) and monokine induced by interferon-gamma ( MIG ) cause tissue necrosis, and interleukin (IL)-18 induces the expression of IFN-gamma and Fas ligand (FasL) by T and natural killer ( NK ) cells
Lee et al., J Hepatol 2002 (Carcinoma, Hepatocellular...) : Neutralizing anti-IL-18 antibodies blocked the expression of FasL, suggesting that IL-18 plays a critical role in FasL expression
Duan et al., Clin Cancer Res 2004 (Osteosarcoma) : The purpose of these studies was to determine whether alkylating agents affect the expression of Fas ligand (FasL) and whether interleukin 12 enhances the sensitivity of human OS cells to alkylating agents
Kitaura et al., Immunol Lett 2006 : Furthermore, IL-18 and IL-12 synergistically induced apoptosis of adherent bone marrow cells in the presence of TNF-alpha, and up-regulated FasL transcription in non-adherent cells
Kang et al., Amino Acids 2007 (Uterine Cervical Neoplasms) : Both mitomycin C and cisplatin induced apoptosis in C-33A cells via caspase-8 and -3 processing in a Fas/FasL dependent manner and also suppressed IL-18 expression, while they down-regulated IkappaB expression and up-regulated p65 expression
Iannello et al., J Virol 2009 (Acquired Immunodeficiency Syndrome) : IL-18 induced the expression of FasL on NK cells, increased the transcription from the human FasL promoter, reduced the expression of Bcl-X ( L ) in NK cells, and increased their sensitivity to FasL mediated cell death
Xu et al., Zhonghua Zhong Liu Za Zhi 2010 (Colonic Neoplasms) : The FasL expression of human colon cancer cells may be regulated by endogenous interleukin-18 in the host microenvironment and enhance the liver colonization competence of colon cancer cells through induction of apoptosis in the Fas expressing hepatocytes
Zhang et al., American journal of physiology. Renal physiology 2011 (Ureteral Obstruction) : Renal obstruction induced a significant increase in IL-18 production, renal tubular cell apoptosis, caspase activation, and FasL expression
Kitaura et al., Clin Dev Immunol 2013 (Arthritis, Rheumatoid...) : IL-12, IL-18, and IFN- ? induce apoptosis in bone marrow cells treated with TNF- a ??in vitro, and osteoclastogenesis is inhibited by the interactions of TNF- a -induced Fas and Fas ligand induced by IL-12, IL-18 , and IFN- ?
Ohtsuki et al., Anticancer Res 1997 (Leukemia, Myelomonocytic, Acute) : Interleukin 18 enhances Fas ligand expression and induces apoptosis in Fas expressing human myelomonocytic KG-1 cells ... In conclusion, IL-18 enhances the expression of Fas ligand by Fas expressing KG-1 cells and induces apoptosis in the cells through a mechanism probably involving the Fas pathway
Kashiwamura et al., Nihon rinsho. Japanese journal of clinical medicine 1998 (Autoimmune Diseases...) : However, recent studies suggested that, IL-18 also enhances expression of FasL and NK activity as well as GM-CSF production
Dinarello et al., J Allergy Clin Immunol 1999 : IL-18 induces gene expression and synthesis of TNF, IL-1, Fas ligand , and several chemokines