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IL15 — JAK1
Text-mined interactions from Literome
Subramaniam et al., Biochem Biophys Res Commun 1999
:
Immunoprecipitation with specific antibodies followed by Western blot analysis with antiphosphotyrosine antibody has shown that in U937 cells,
interleukin-17 induces time dependent stimulation of tyrosine phosphorylation of
JAK 1 , 2 and 3, Tyk 2 and STAT 1, 2, 3 and 4 within 0.5 to 30 min. Interleukin-17 mediated tyrosine phosphorylation of these proteins strongly suggests that the JAK/STAT signaling pathway may play a major role in transducing signals from interleukin-17 receptors to the nucleus
To et al., Br J Cancer 2004
(Cell Transformation, Neoplastic...) :
The
interleukin mediated
Janus kinase ( JAK ) /STAT pathway plays a crucial role in carcinogenesis
Walker et al., Arch Virol Suppl 2005
(Ehrlichiosis) :
Ehrlichiae attach to L-selectin and E-selectin,
inhibit phagolysosomal fusion, apoptosis, and
JAK/STAT activation, and downregulate IL-12,
IL-15 , IL-18, TLR2 and 3, and CD14
Hanisch et al., J Biol Chem 1997
:
Tyrosine phosphorylation data are presented showing that
IL-15 signaling in microglia
involves Janus kinase 1 activity
Waldmann et al., Int Rev Immunol 1998
:
In mast cells,
IL-15 signaling
involves JAK-2 and STAT-5 activation rather than the
JAK-1 and JAK-3 as well as the STAT-3 and STAT-5 used by both IL-2 and IL-15 in activated T cells