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GAL — GALR1

Pathways - manually collected, often from reviews:

• Reactome Reaction: GAL → GALR1 (direct_complex) Bersani et al., FEBS Lett 1991*, Schmidt et al., Proc Natl Acad Sci U S A 1991*, Habert-Ortoli et al., Proc Natl Acad Sci U S A 1994*, Fathi et al., Brain Res Mol Brain Res 1998*, Smith et al., J Biol Chem 1998*, Kolakowski et al., J Neurochem 1998*
• Reactome Reaction: GAL → GALR1 (reaction) Bersani et al., FEBS Lett 1991*, Schmidt et al., Proc Natl Acad Sci U S A 1991*, Lambert et al., Science signaling 2008, Lerea et al., Neuron 1989, Van Dop et al., Nucleic Acids Res 1989, Itoh et al., J Biol Chem 1988, Habert-Ortoli et al., Proc Natl Acad Sci U S A 1994*, Takami et al., Brain Res Mol Brain Res 1994, Fathi et al., Brain Res Mol Brain Res 1998*, Smith et al., J Biol Chem 1998*, Kolakowski et al., J Neurochem 1998*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: GALR1 — GAL (in vivo) Habert-Ortoli et al., Proc Natl Acad Sci U S A 1994*, Kask et al., EMBO J 1996*, Fitzgerald et al., J Pharmacol Exp Ther 1998*
• IRef Hprd Interaction: GALR1 — GAL (in vitro) Habert-Ortoli et al., Proc Natl Acad Sci U S A 1994*, Kask et al., EMBO J 1996*, Fitzgerald et al., J Pharmacol Exp Ther 1998*
• IRef Intact Interaction: Complex of GAL-GALR1-GAL (physical association, scintillation proximity assay) Bono et al., Cancer Cell 2013
• IRef Intact Interaction: GALR1 — GAL (physical association, scintillation proximity assay) Bono et al., Cancer Cell 2013
• IRef Ophid Interaction: GALR1 — GAL (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Liu et al., Proc Natl Acad Sci U S A 2001 (Causalgia...) : These data indicate that a low dose of galanin has a nociceptive role at the spinal cord level mediated by GalR2 receptors, whereas the antiallodynic effect of high-dose galanin on neuropathic pain is mediated by the GalR1 receptors
Jacoby et al., Brain Res Mol Brain Res 2002 (Body Weight...) : Critical role for GALR1 galanin receptor in galanin regulation of neuroendocrine function and seizure activity ... The phenotype of these mice identifies a critical role for GALR1 in neuroendocrine regulation and in mediating the anti-seizure activity of galanin
Giustina et al., Metabolism 1992 (Acromegaly) : Failure of galanin to enhance GH response to GHRH in acromegalic patients could be due to a change in function of the galanin receptor on GH-secreting adenomatous cells
Anselmi et al., J Neurosci Res 2009 : In the gastrointestinal tract, GalR1 mediates the galanin inhibition of cholinergic transmission to the longitudinal muscle and reduction of peristalsis efficiency in the small intestine
Xu et al., PloS one 2012 (Hyperalgesia...) : In the present study, sciatic nerve-pinch injury rat model was used to determine the effects of exogenous Gal on the expression of the Gal and its receptors ( GalR1 , GalR2 ) in DRG and SDH, the alterations of pain behavior, nerve conduction velocity ( NCV ) and morphology of sciatic nerve
Anderson et al., Behav Brain Res 2013 : Taken together, these results show that galanin may be playing a role in decreasing motivation at times of high appetitive behavior, and that this effect is likely mediated by the GalR1 receptor