Gene interactions and pathways from curated databases and text-mining

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FAS — PDLIM7

Text-mined interactions from Literome

Le Clorennec et al., J Virol 2008 : LMP1 induced Fas overexpression with its relocalization in lipid raft microdomains of the membrane ... Therefore, our results are in agreement with a model where LMP1 dependent NF-kappaB activation induces Fas overexpression and autoactivation that could overwhelm the antiapoptotic effect of NF-kappaB, revealing an ambivalent function of LMP1 in cell survival and programmed cell death
Zhang et al., Chin J Cancer 2009 (Disease Susceptibility...) : As a nuclear factor-kappaB (NF-kappaB) dependent molecule, Fas is induced by LMP1 , and LMP1 enhances Fas mediated apoptosis, according to our finding of stimulus dependent apoptosis regulation by LMP1