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EPO — HIF1A
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Pastore et al., Am J Hum Genet 2003
(Anoxia...) :
In hypoxia or secondary to a mutated VHL gene, the nondegraded
HIF-1 alpha forms a heterodimer with HIF-beta and
leads to increased transcription of hypoxia-inducible genes, including
erythropoietin (EPO)
Hale et al., Gynecol Oncol 2006
(Neovascularization, Pathologic...) :
The objective of this study was to evaluate the
effects of recombinant
erythropoietin (EPO) on
HIF-1alpha induced angiogenic pathways in ovarian cancer cells
Liu et al., J Neurochem 2006
(Brain Ischemia...) :
Our results indicate that
HIF-1alpha induces
EPO gene released by astrocytes and acts as an essential mediator of neuroprotection, prove the protective role of intrinsic astrocytic-neuronal signaling pathway in hypoxic/ischemic injury and demonstrate an optimal therapeutic time-window of extrinsic rhEPO in ischemia/reperfusion injury in vitro
Ratcliffe et al., J Clin Invest 2007
:
In this issue of the JCI, Rankin and colleagues show, using targeted gene inactivation, that induction of
Epo expression in murine liver is
dependent on the integrity of HIF-2alpha, and not
HIF-1alpha ( see the related article beginning on page 1068 )
Rankin et al., J Clin Invest 2007
(Disease Models, Animal...) :
Furthermore, we found that physiological
Epo expression in infant livers
required Hif-2alpha but not
Hif-1alpha and that the hypoxic induction of liver Epo in anemic adults was Hif-2alpha dependent
Diensthuber et al., Otol Neurotol 2007
(Disease Progression...) :
Erythropoietin expression is
regulated by the transcription factor,
HIF-1alpha
Oki et al., Nihon rinsho. Japanese journal of clinical medicine 2008
:
The
Epo gene expression is
controlled by
HIF-1alpha
Fan et al., Brain Res Rev 2009
(Hypoxia-Ischemia, Brain...) :
HIF-1alpha regulates the transcription of
erythropoietin (EPO) , which induces several pathways associated with neuroprotection
Zhang et al., Front Biosci (Elite Ed) 2010
(Diabetic Retinopathy) :
The increased protein levels of
HIF-1 alpha , VEGF-A, and endogenous EPO found in diabetic retinas also have been
down-regulated by exogenous
EPO