◀ Back to CREB1
CREB1 — MAPKAPK2
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
CREB1
→
MAPKAPK2
(increases, MAPKAPK2 Activity, CREB1 Activity)
Deak et al., EMBO J 1998
Evidence: MSK1 is localized in the nucleus of unstimulated or stimulated cells, and phosphorylates CREB at Ser133 with a Km value far lower than PKA, MAPKAP-K1(p90Rsk) and MAPKAP-K2.
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Reactome Reaction:
CREB1
→
MAPKAPK2
(reaction)
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WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling:
MAPKAPK2
→
CREB1
(mim-necessary-stimulation)
Pomerance et al., J Biol Chem 2000*, Sung et al., J Biol Chem 2001*, Tan et al., EMBO J 1996*, Chen et al., J Biol Chem 1998*
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WikiPathways p38 MAPK Signaling Pathway:
MAPKAPK2
→
CREB1
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Miguel et al., J Biol Chem 2005
(MAP Kinase Signaling System) :
These data define a novel mitogenic signaling pathway in osteoblasts whereby ERK1/2 stimulation of
CREB phosphorylation and transcriptional activity as well as DNA synthesis are critically
dependent on de novo
Mapkapk2 synthesis
Tan et al., EMBO J 1996
:
We show that MAPKAP kinase-2 phosphorylates CREB at Ser133 in vitro, that the FGF- or stress induced
activation of
MAPKAP kinase-2 and phosphorylation of
CREB and ATF-1 are prevented by similar concentrations of the specific p38 MAP kinase inhibitor SB 203580, and that MAPKAP kinase-2 is the only detectable SB 203580-sensitive CREB kinase in SK-N-MC cell extracts