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BRCA1 — PRL

Text-mined interactions from Literome

Favy et al., Biochem Biophys Res Commun 1999 : Prolactin dependent up-regulation of BRCA1 expression in human breast cancer cell lines ... Using competitive RT-PCR, we have shown that PRL induced an increase in BRCA1 mRNA level in MCF-7 and T-47D cell lines at a dose resulting in the maximal enhancement of cell proliferation ... At the protein level, PRL treatment induced a 4-fold increase of BRCA1 protein expression in MCF-7 and a 6-fold increase in T-47D cells, whereas BRCA1 protein expression was not affected by PRL in MCF10a
Favy et al., Anticancer Res 2000 (Breast Neoplasms) : Cyclosporine A inhibition of prolactin dependent up-regulation of BRCA1 protein expression in human breast cell lines ... Previously, we reported experimental evidence that BRCA1 , breast and ovarian cancer susceptibility gene is up-regulated in response to Prolactin stimulation ... This emphasized the hypothesis that BRCA1 may be stimulated by Prolactin
Vidarsson et al., FEBS Lett 2002 (Breast Neoplasms) : Here we show that Stat5a forms a complex with both BRCA1 and BRCA2 in breast epithelial cells upon stimulation with prolactin