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BCL2 — IFI27
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Kim et al., Cancer Lett 2000
:
These findings indicate that
p27 ( kip1 ) may play important roles in mediating ceramide induced apoptosis and its expression can be
regulated by Bax and
Bcl-2
Fahy et al., J Surg Res 2003
(Adenocarcinoma...) :
Bortezomib treatment led to accumulation of p21 ( WAF1/CIP1 ) and p27 ( KIP1 ) and decreased BCL-2 ; gemcitabine decreased
p27 ( KIP1 ),
induced BCL-2 and had no effect on p21 ( WAF1/CIP1 )
Festuccia et al., Endocr Relat Cancer 2009
(Disease Models, Animal...) :
In vivo, azacitidine ( 0.8 mg/kg i.p. ) reduced tumor proliferation and induced apoptosis in both xenografts upmodulating the expression of p16INKA, Bax, Bak, p21/WAF1, and
p27/KIP1 , and
inhibiting the activation of Akt activity and the expression of cyclin D1, Bcl-2, and
Bcl-XL ... In vivo, azacitidine ( 0.8 mg/kg i.p. ) reduced tumor proliferation and induced apoptosis in both xenografts upmodulating the expression of p16INKA, Bax, Bak, p21/WAF1, and
p27/KIP1 , and
inhibiting the activation of Akt activity and the expression of cyclin D1,
Bcl-2 , and Bcl-XL
Chen et al., J Huazhong Univ Sci Technolog Med Sci 2010
(Carcinoma, Hepatocellular...) :
Effects of
Ad-p27mt gene transfer on the expression of Bax,
Bcl-2 , VEGF and MMP-9 in the transplanted liver tumors in nude mice
Ganapathy et al., PloS one 2010
(Neoplasm Metastasis...) :
In xenografted tumors, resveratrol upregulated the expressions of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax and
p27 ( /KIP1 ), and
inhibited the expression of
Bcl-2 and cyclin D1