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NF2 — PAK1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
PAK1
—
NF2
Kissil et al., Mol Cell 2003*
-
IRef Bind_translation Interaction:
PAK1
—
NF2
(affinity chromatography technology)
Kissil et al., Mol Cell 2003*
-
IRef Bind_translation Interaction:
PAK1
—
NF2
(coimmunoprecipitation)
Kissil et al., Mol Cell 2003*
-
IRef Hprd Interaction:
NF2
—
PAK1
(in vitro)
Xiao et al., J Biol Chem 2002*, Kissil et al., Mol Cell 2003*
-
IRef Hprd Interaction:
NF2
—
PAK1
(in vivo)
Xiao et al., J Biol Chem 2002*, Kissil et al., Mol Cell 2003*
-
IRef Intact Interaction:
PAK1
—
NF2
(physical association, anti tag coimmunoprecipitation)
Yi et al., Cancer Cell 2011
-
IRef Ophid Interaction:
PAK1
—
NF2
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Kissil et al., Mol Cell 2003
(Cell Transformation, Neoplastic...) :
Merlin inhibits the activation of
Pak1 , as the loss of merlin expression results in the inappropriate activation of Pak1 under conditions associated with low basal activity
Hirokawa et al., Cancer J 2004
(Cell Transformation, Neoplastic...) :
Here, using a series of NF2 constructs, we show that
NF2 inhibits directly the Rac/CDC42 dependent Ser/Thr kinase
PAK1 , which is essential for both Ras transformation and neurofibromatosis type 1 (NF1), through two separate domains